{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T10:10:39Z","timestamp":1794305439154,"version":"4.9.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T00:00:00Z","timestamp":1334188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Local heating induces biphasic cutaneous vasodilation in non\u2010glabrous skin of the forearm. However, little data exist in other skin regions, despite the prevalence of facial flushing disorders. We hypothesized that facial skin will have greater initial peak responses to local heating than forearm skin because of neural differences between sites and, furthermore, axon reflex vasodilation will be eliminated in facial sites with sensory blockade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin blood flow (laser\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler flowmetry) responses of healthy, non\u2010obese subjects to local heating (32\u201342\u00b0C in ~5\u00a0min, held 40\u00a0min) in the forehead (<jats:italic>n<\/jats:italic>\u00a0=\u00a022), cheek (<jats:italic>n<\/jats:italic>\u00a0=\u00a022), forearm (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) and palm (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) were expressed as percentage of maximum cutaneous vascular conductance (<jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>; flux\/mean arterial pressure). In an additional group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), sensation was blocked (topical prilocaine\u2010lidocaine) prior to the local heating protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to heating, <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> differences were noted (forearm\u00a0=\u00a010\u00a0\u00b1\u00a03, cheek\u00a0=\u00a019\u00a0\u00b1\u00a03, forehead\u00a0=\u00a016\u00a0\u00b1\u00a01 and palm\u00a0=\u00a065\u00a0\u00b1\u00a011%<jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>;<jats:italic> P<\/jats:italic>&lt;0\u00b705). Initial peak <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> was similar between forehead, cheek and forearm (85\u00a0\u00b1\u00a03, 92\u00a0\u00b1\u00a02, and 91\u00a0\u00b1\u00a06%<jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>, respectively), but elevated in the palm (120\u00a0\u00b1\u00a08%<jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>;<jats:italic> P<\/jats:italic>&lt;0\u00b705). Compared to facial control sites, sensory blockade delayed increases in both cheek and forehead (<jats:italic>P<\/jats:italic>&lt;0\u00b705) <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> but did not change magnitude of the biphasic response (<jats:italic>P<\/jats:italic>&gt;0\u00b705).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data indicate that facial skin initial <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> peaks to local heating are similar to non\u2010glabrous skin. In contrast to forearm responses, facial topical sensory blockade does not abate axon reflex responses to local heating. Palm skin data indicate that maximal skin blood flow is not obtained during local heating as it is in non\u2010glabrous skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1475-097x.2012.01137.x","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T06:32:02Z","timestamp":1334212322000},"page":"361-366","source":"Crossref","is-referenced-by-count":23,"title":["Differential vasodilatory responses to local heating in facial, glabrous and hairy skin"],"prefix":"10.1111","volume":"32","author":[{"given":"Kristen","family":"Metzler\u2010Wilson","sequence":"first","affiliation":[{"name":"Ohio Musculoskeletal and Neurologic Institute Ohio University Athens OH USA"},{"name":"School of Rehabilitation and Communication Sciences Ohio University Athens OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Kellie","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurologic Institute Ohio University Athens OH 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