{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:40:00Z","timestamp":1778668800679,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Physio Funct Imaging"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Baroreflex sensitivity (<jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content>) reflects the effectiveness of cardiac parasympathetic regulation. <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> becomes impaired in stable coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) and after myocardial infarction and carries prognostic information in these patients. Whether impaired <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> is found already in asymptomatic subjects, with subclinical coronary atherosclerosis, has remained elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The relationship between <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> and coronary atherosclerosis was evaluated in 31 subjects with high familial risk for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> but without evidence of angina pectoris or myocardial ischaemia. Single photon emission tomography was performed with <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi to rule out myocardial perfusion defects at rest and during exercise. <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> was assessed by phenylephrine technique. Coronary atherosclerosis was analysed by quantitative coronary angiography (<jats:styled-content style=\"fixed-case\">QCA<\/jats:styled-content>). Percentage of diameter stenosis (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) was calculated separately for <jats:styled-content style=\"fixed-case\">LAD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LCX<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RCA<\/jats:styled-content> coronary arteries as well as for proximal (<jats:styled-content style=\"fixed-case\">PROX<\/jats:styled-content>), middle (<jats:styled-content style=\"fixed-case\">MID<\/jats:styled-content>) and distal (<jats:styled-content style=\"fixed-case\">DIST<\/jats:styled-content>) coronary artery regions; and for all coronary artery regions (global <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baroreflex sensitivity averaged 7\u00b78\u00a0\u00b1\u00a05\u00b74\u00a0ms\u00a0mmHg<jats:sup>\u22121<\/jats:sup>. <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> showed inverse correlation to <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> of the proximal coronary artery segments (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b7315; <jats:italic>P<\/jats:italic>&lt;0\u00b705) and with the most severe single coronary artery stenosis (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b7374; <jats:italic>P<\/jats:italic>&lt;0\u00b705). Five (16%) subjects had <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content>\u00a0\u2264\u00a03\u00a0ms\u00a0mmHg<jats:sup>\u22121<\/jats:sup>. They had more severe <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> of proximal coronary artery segment than subjects with <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content>\u00a0&gt;\u00a03\u00a0ms\u00a0mmHg<jats:sup>\u22121<\/jats:sup> (24\u00a0\u00b1\u00a07% versus 13\u00a0\u00b1\u00a011%, <jats:italic>P<\/jats:italic>&lt;0\u00b705, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Impairment of <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> was found to be associated with the severity of subclinical coronary atherosclerosis in healthy asymptomatic subjects with familial risk of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. Asymptomatic subjects with severely blunted <jats:styled-content style=\"fixed-case\">BRS<\/jats:styled-content> may have advanced coronary atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1475-097x.2012.01165.x","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T03:37:55Z","timestamp":1347421075000},"page":"70-74","source":"Crossref","is-referenced-by-count":14,"title":["Baroreflex sensitivity in asymptomatic coronary atherosclerosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Sakari","family":"Simula","sequence":"first","affiliation":[{"name":"Department of Neurology Mikkeli Central Hospital Mikkeli Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomi","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esko","family":"Vanninen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Pajunen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Syv\u00e4nne","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Hedman","sequence":"additional","affiliation":[{"name":"Heart Center Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Hartikainen","sequence":"additional","affiliation":[{"name":"Heart Center Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.03.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.08.043"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.67.2.129"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.10.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060423"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90443-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.140665"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00525-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.4.816"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.16.2072"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2008.00219.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.034"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.2.576"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000198024.91976.c2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00420-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00035-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.04.038"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.089"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.4.969"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.6.1351"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000236507.76042.72"},{"key":"e_1_2_7_24_1","first-page":"1","article-title":"Cardiac adrenergic innervation is affected in asymptomatic subjects with early stage of coronary artery disease","volume":"43","author":"Simula S","year":"2002","journal-title":"J Nucl Med"},{"key":"e_1_2_7_25_1","unstructured":"World Medical Association.World Medical Association Declaration of Helsinki \u2013 Ethical principles for medical research involving human subjects. 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