{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:22:03Z","timestamp":1767795723382,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2007,3]]},"abstract":"Abstract<\/jats:title>\n \n Background:\u2002<\/jats:bold>\n Blue colouration of the sclera is a distinctive feature of unknown aetiology in osteogenesis imperfecta (OI). It has value as a diagnostic marker, for distinguishing prognostically distinct subtypes of the condition, and has been reported to undergo rapid unexplained changes concurrently to fractures. Description of the feature is currently hampered by lack of a clinical tool.\n <\/jats:p>\n \n Methods:\u2002<\/jats:bold>\n A range of blue reference colour chips from an internationally recognized standard (the Munsell system) was used under standardized viewing conditions, by two independent observers with normal colour perception, to classify the scleral colour of affected individuals.\n <\/jats:p>\n \n Results:\u2002<\/jats:bold>\n A total of 43 individuals affected by OI of a wide variety of severity with ages from 5 to 63\u2003years were observed. All individuals in the sample had blue sclerae, and all colours seen could be matched to a Munsell standard within the hue range of 7.5B (blue) to 5PB (purple\u2010blue). There was little variation in observed chroma (saturation), and observations of hue showed poor inter\u2010observer reliability (\n r<\/jats:italic>\n \u2003=\u20030.17\u2003\u00b1\u20030.34: 95% CI). However, levels of value (lightness) showed wide variability and good inter\u2010observer reliability (\n r<\/jats:italic>\n \u2003=\u20030.63\u2003\u00b1\u20030.14: 95% CI).\n <\/jats:p>\n \n Conclusions:\u2002<\/jats:bold>\n A practical tool for the description of the colour of the sclera in individuals with OI can be constructed using the colours from the Munsell system varying in value (lightness) with hue: 2.5 PB and chroma: 2.\n <\/jats:p>","DOI":"10.1111\/j.1475-1313.2006.00467.x","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T19:06:23Z","timestamp":1172516783000},"page":"174-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A standardized tool to measure and describe scleral colour in osteogenesis imperfecta"],"prefix":"10.1007","volume":"27","author":[{"given":"Philip","family":"Zack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda R.","family":"Zack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Surtees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian G. R.","family":"Neville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,2,26]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"American Society for Testing and Materials (ASTM): D1729\u201096 (2003) Standard Practice for Visual Appraisal of Color and Color Differences of Diffusely\u2010Illuminated Opaque Materials","author":"Anon","year":"2003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040437014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0026256"},{"key":"e_1_2_6_5_1","first-page":"646","article-title":"Electron microscopy findings in the cornea and sclera in osteogenesis imperfecta","volume":"161","author":"Eichholtz W.","year":"1972","journal-title":"Klin. Monatsbl. Augenheilkd."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2002.00062.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00209.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275682"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900719"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.101"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320450207"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1475-1313.2006.00467.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1475-1313.2006.00467.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:24:50Z","timestamp":1767785090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1475-1313.2006.00467.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,26]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1111\/j.1475-1313.2006.00467.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1475-1313.2006.00467.x","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,26]]},"assertion":[{"value":"2007-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}