{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:22:22Z","timestamp":1767795742979,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Purpose:\u2002<\/jats:bold>\n                    To investigate the presence of silent cardiac ischaemic episodes and the status of autonomic function in consecutive, newly diagnosed and untreated primary open\u2010angle glaucoma patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Twenty\u2010four consecutively diagnosed glaucoma patients and 22 age\u2010matched controls were subjected to ambulatory 24\u2010h blood pressure (BP) and electrocardiogram (ECG) monitoring by using Cardiotens\u201001 (Meditech Ltd). Based on the ECG recordings, heart rate variability (HRV) frequency domain parameters [low\u2010frequency (LF), high\u2010frequency (HF) and LF\/HF ratio] were calculated and analysed in the two study groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Glaucoma patients demonstrated higher LF and LF\/HF values than normal subjects for both the active period (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.020 and 0.029) and the passive period (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.044 and 0.049 respectively). HRV parameters were similar in patients and controls suffering from silent cardiac ischaemia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003&gt;\u20030.05); however, glaucoma patients with normal ECG demonstrated higher LF and LF\/HF values during the active period of the 24\u2010h measurement period than control subjects characterized by the same cardiac activity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.010 and 0.021 respectively).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Independent of a history and\/or clinical signs of cardiovascular disease, glaucoma patients exhibit abnormal autonomic function.\n                  <\/jats:p>","DOI":"10.1111\/j.1475-1313.2007.00485.x","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T09:20:57Z","timestamp":1179739257000},"page":"336-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Autonomic dysfunction in unselected and untreated primary open angle glaucoma patients: a pilot study"],"prefix":"10.1007","volume":"27","author":[{"given":"Doina","family":"Gherghel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Louise","family":"Hosking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian Andrew","family":"Cunliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,6,18]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"The Autonomic Nervous System","author":"Appenzeller O.","year":"1997"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00171383"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1042\/cs1020623","article-title":"Impaired cardiovascular responses to baroreflex stimulation in open angle and normal\u2010pressure glaucma","volume":"102","author":"Brown C. 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