{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:33:42Z","timestamp":1777988022883,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Purpose:\u2002<\/jats:bold>\n                    To characterize clinical signs and symptoms in a group of post\u2010menopausal (PM) females who present with and without symptoms of dry eye.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Eighty\u2010three healthy PM females were categorized as being symptomatic or asymptomatic of dry eye based on their response to the Allergan Ocular Surface Disease Index\n                    <jats:sup>\u00a9<\/jats:sup>\n                    (OSDI) questionnaire. Non\u2010invasive tear breakup time (NITBUT) was evaluated using the ALCON Eyemap\u00ae. Tear volume was assessed using the phenol red thread (PRT) test and bulbar conjunctival hyperaemia was measured using objective and subjective methods.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    The total OSDI score (TOS) and subscores for the non\u2010dry eye (NDE;\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200339) and dry eye (DE;\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200344) groups were significantly different (TOS: NDE\u2003=\u20037.43\u2003\u00b1\u20037.71 vs DE\u2003=\u200324.87\u2003\u00b1\u200313.89;\n                    <jats:italic>p<\/jats:italic>\n                    \u2003&lt;\u20030.001). The DE group exhibited a shorter NITBUT (5.3\u2003\u00b1\u20031.7\u2003s vs 7.0\u2003\u00b1\u20032.7\u2003s;\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.0012). Tear volume was lower for the DE group (19.3\u2003\u00b1\u20035.1\u2003mm vs 16.3\u2003\u00b1\u20035.6\u2003mm;\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.031). Bulbar hyperaemia was higher in the DE group for both subjective grading using a modified CCLRU scale (48.4\u2003\u00b1\u200310.0 vs 40.6\u2003\u00b1\u200310.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.0011) and objective measurement by spectrophotometer (Commission Internationale de l\u2019Eclairage u\u2019 value\u2003=\u20030.285\u2003\u00b1\u20030.006 vs 0.282\u2003\u00b1\u20030.006;\n                    <jats:italic>p<\/jats:italic>\n                    \u2003=\u20030.005).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    OSDI can be used to separate PM females who demonstrate clinical signs of ocular dryness. PM women with dry eye symptoms demonstrate shorter NITBUT, lower tear volume and increased bulbar conjunctival hyperaemia than those who have no symptoms.\n                  <\/jats:p>","DOI":"10.1111\/j.1475-1313.2008.00580.x","type":"journal-article","created":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T09:20:53Z","timestamp":1213694453000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical signs and symptoms in post\u2010menopausal females with symptoms of dry eye"],"prefix":"10.1007","volume":"28","author":[{"given":"Sruthi","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Senchyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trefford","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndon","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076148"},{"key":"e_1_2_8_3_1","first-page":"2469","article-title":"Self\u2010reported assessment of dry eye in a population\u2010based setting","volume":"38","author":"Bandeen\u2010Roche K.","year":"1997","journal-title":"Invest. 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