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Patients were then randomized to receive either<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b\u2010200 (<jats:italic>N<\/jats:italic>= 10) or<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>450\/0.7 (<jats:italic>N<\/jats:italic>= 10). Balanced isotonic replacement crystalloids (10\u201320 mL\/kg<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) were rapidly infused along with either<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b\u2010200 or<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>in 5 mL\/kg<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>aliquots to meet resuscitation end points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Resuscitation was defined as meeting at least 2 of 3 criteria: (1) capillary refill time 1\u20132 seconds, pink mucous membrane color, strong femoral pulse quality; (2) heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) \u2264 150\/min; or (3) indirect arterial systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) &gt; 90 mm<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g.<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>, packed cell volume, hemoglobin, glucose, venous p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>, bicarbonate, base excess, anion gap, and colloid osmotic pressure were compared at hospital entry and within 30 minutes post\u2010resuscitation. Compared to the<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>group, the<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b\u2010200 group required significantly less colloid (4.2 versus 18.4 mL\/kg) and crystalloid (31.3 versus 48.1 mL\/kg) to reach resuscitation end points (<jats:italic>P<\/jats:italic>= 0.001). Time to resuscitation was significantly shorter in the<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b\u2010200 group (12.5 versus 52.5 min).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dogs with<jats:styled-content style=\"fixed-case\">GDV<\/jats:styled-content>receiving<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b\u2010200 during initial resuscitation required smaller volumes of both crystalloid and colloid fluids and reached resuscitation end points faster than dogs receiving<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>450\/0.7 (<jats:italic>P<\/jats:italic>= 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