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Expert\u2010based veterinary guidelines recommend the use of pimobendan in the management of acute, hospital\u2010based therapy for patients with CHF attributable to CVHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of pimobendan, an inodilator with phosphodiesterase 3 (PDE3) inhibitory and calcium\u2010sensitizing properties, is regarded as a component of the standard of care in the management of dogs with CHF secondary to both DCM and CVHD. Further studies are warranted to confirm the safety and efficacy of pimobendan for the off\u2010label use of this drug in asymptomatic CVHD, pulmonary arterial hypertension, asymptomatic myocardial diseases, CHF from all other causes and in cats with CHF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1476-4431.2012.00768.x","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T02:26:46Z","timestamp":1346207206000},"page":"398-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["A review of the pharmacology and clinical uses of pimobendan."],"prefix":"10.1111","volume":"22","author":[{"given":"Kimberly L.","family":"Boyle","sequence":"first","affiliation":[{"name":"From the VCA All\u2010Care Animal Referral Center Fountain Valley CA 92708"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Leech","sequence":"additional","affiliation":[{"name":"From the VCA All\u2010Care Animal Referral Center Fountain Valley CA 92708"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2009.00800.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2010.00966.x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0150.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02366.x"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0116.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01847.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.125620"},{"issue":"2","key":"e_1_2_14_10_1","first-page":"85","article-title":"Cardiac manifestations of digoxin intoxication. 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