{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:14:09Z","timestamp":1699143249319},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":15754,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1969,6]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>. A biliary fistula was prepared in twelve sheep.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>. Each animal was given 2 ml. of <jats:sup>14<\/jats:sup>C\u2010carbon tetrachloride (specific activity 15 mc\/m\u2010mole) and bile collected at 2, 4, 24 and 48 hr.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>. Specific activity was measured by liquid scintillation counting before and after each specimen had been heated to 75\u00b0C for 10 min to drive off volatile content (carbon tetrachloride).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>. Only traces of activity were present in the bile and heating did not alter this.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>. There was no difference in the survival times of adult <jats:italic>Fasciola hepatica<\/jats:italic> incubated in Hedon Flieg medium with and without 25% bile from non\u2010medicated sheep, or with carbon tetrachloride in a concentration of 0.03%, but 25% of bile from sheep given 2 ml. of carbon tetrachloride 24 hr before greatly increased lethality <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>. The anthelmintic action of carbon tetrachloride on <jats:italic>F. hepatica<\/jats:italic> does not result from a direct action due to excretion in bile of unchanged carbon tetrachloride but of an unidentified toxic element not necessarily derived from the drug but which arises as a result of its administration.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1969.tb09502.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T02:02:59Z","timestamp":1342749779000},"page":"253-256","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The mode of action of carbon tetrachloride on <i>Fasciola hepatica<\/i>"],"prefix":"10.1111","volume":"36","author":[{"given":"A.","family":"KHALIDI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANIHA AMIN","family":"ZAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/174654a0"},{"key":"e_1_2_1_3_1","first-page":"113","volume-title":"Veterinary Applied Pharmacology and Therapeutics","author":"Daykin P. 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Ther."}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.1969.tb09502.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.1969.tb09502.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T13:28:08Z","timestamp":1699104488000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.1969.tb09502.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,6]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,6]]}},"alternative-id":["10.1111\/j.1476-5381.1969.tb09502.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.1969.tb09502.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,6]]},"assertion":[{"value":"2012-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}