{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:23:31Z","timestamp":1777998211139,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T00:00:00Z","timestamp":1342742400000},"content-version":"vor","delay-in-days":15329,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1970,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Human blood platelets have been shown to take up dopamine by an energy\u2010dependent, saturable process that is inhibited by 5\u2010hydroxytryptamine (5\u2010HT), desipramine and other drugs.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Platelets from parkinsonian subjects receiving oral <jats:sc>l<\/jats:sc>\u2010DOPA also took up dopamine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>When the responses of normal and parkinsonian platelets were compared, the parkinsonian cells showed the following differences: increased affinity for the dopamine transport process; decreased equilibrium concentrations of dopamine after incubation for 90 min, and greater efflux of dopamine from loaded platelets during a 10 min incubation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>There were no differences in the uptake of 5\u2010HT by parkinsonian platelets, but endogenous 5\u2010HT was significantly reduced; ATP was normal.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In two out of three samples of platelets from parkinsonian subjects, traces of a dopamine\u2010like substance were detected, but this finding requires confirmation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>If the platelet is a valid model for dopaminergic brain neurones, then the results described would suggest that dopamine uptake and storage may be abnormal in brain neurones in Parkinson's disease.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1970.tb09904.x","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T00:21:48Z","timestamp":1342830108000},"page":"779-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with <scp>l<\/scp>\u2010DOPA"],"prefix":"10.1111","volume":"39","author":[{"given":"D. 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