{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:16:23Z","timestamp":1782890183094,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T00:00:00Z","timestamp":1260835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p><jats:bold>Background and purpose:\u2002<\/jats:bold> We determined if chronic sympatho\u2010inhibition with rilmenidine has functional significance for the kidney by altering responses of renal blood flow (RBF) and plasma renin activity (PRA) to stress and acute hypotension in rabbits with renovascular hypertension.<\/jats:p><jats:p><jats:bold>Experimental approach:\u2002<\/jats:bold> RBF to each kidney and renal sympathetic nerve activity (RSNA) to the left kidney were measured in rabbits in which a renal artery clip induced hypertension (2K1C) and in sham\u2010operated rabbits. After 2 weeks, a subcutaneous minipump was implanted to deliver rilmenidine (2.5\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) to 2K1C rabbits for 3 weeks.<\/jats:p><jats:p><jats:bold>Key results:\u2002<\/jats:bold> After 5 weeks of renal artery stenosis, mean arterial pressure (MAP) was 23% higher and PRA 3\u2010fold greater than in sham\u2010operated rabbits. Blood flow and renal vascular conductance in the stenosed kidney were lower (\u221275% and \u221280%) compared with sham, and higher in the non\u2010clipped kidney (68% and 39%). Responses of RBF and PRA to hypotension were similar in 2K1C and sham rabbits. Airjet stress evoked a greater increase in MAP in 2K1C rabbits than sham controls. Chronic rilmenidine normalized MAP, reduced RSNA and PRA, and did not reduce RBF in the stenosed kidney. Responses of RBF (clipped and non\u2010clipped kidney), RSNA and PRA to hypotension and airjet were little affected by rilmenidine.<\/jats:p><jats:p><jats:bold>Conclusions and implications:\u2002<\/jats:bold> Our observations suggest that chronic sympatho\u2010inhibition is an effective antihypertensive therapy in renovascular hypertension. It normalizes MAP and reduces basal PRA without compromising blood flow in the stenosed kidney or altering responses of MAP, haemodynamics and PRA to acute hypotension and stress.<\/jats:p>","DOI":"10.1111\/j.1476-5381.2009.00546.x","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T12:45:54Z","timestamp":1260881154000},"page":"438-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of chronic sympatho\u2010inhibition on reflex control of renal blood flow and plasma renin activity in renovascular hypertension"],"prefix":"10.1111","volume":"159","author":[{"given":"SL","family":"Burke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RG","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GA","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707746"},{"key":"e_1_2_8_3_1","first-page":"82","article-title":"Clonidine versus methyldopa. 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