{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:52:22Z","timestamp":1789487542744,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background and purpose:\u2002<\/jats:bold>\n                    Hydrogen sulphide is an important mediator of gastric mucosal defence. The use of non\u2010steroidal anti\u2010inflammatory drugs continues to be limited by their toxicity, particularly in the upper gastrointestinal tract. We evaluated the gastrointestinal safety and anti\u2010inflammatory efficacy of a novel hydrogen sulphide\u2010releasing derivative of naproxen, ATB\u2010346 [2\u2010(6\u2010methoxy\u2010napthalen\u20102\u2010yl)\u2010propionic acid 4\u2010thiocarbamoyl\u2010phenyl ester].\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Experimental approach:\u2002<\/jats:bold>\n                    The ability of ATB\u2010346 versus naproxen to cause gastric damage was evaluated in healthy rats and in rats with compromised gastric mucosal defence. Effects on the small intestine and on the healing of ulcers were also assessed. The ability of ATB\u2010346 to inhibit cyclooxygenase\u20101 and 2 and to reduce inflammation\n                    <jats:italic>in vivo<\/jats:italic>\n                    was also evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Key results:\u2002<\/jats:bold>\n                    ATB\u2010346 suppressed gastric prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    synthesis as effectively as naproxen, but produced negligible damage in the stomach and intestine. In situations in which the gastric mucosa was rendered significantly more susceptible to naproxen\u2010induced damage (e.g. ablation of sensory afferent nerves, inhibition of endogenous nitric oxide or hydrogen sulphide synthesis, co\u2010administration with aspirin, antagonism of K\n                    <jats:sub>IR<\/jats:sub>\n                    6.x channels), ATB\u2010346 did not cause significant damage. Unlike naproxen and celecoxib, ATB\u2010346 accelerated healing of pre\u2010existing gastric ulcers. In a mouse airpouch model, ATB\u2010346 suppressed cyclooxygenase\u20102 activity and inhibited leukocyte infiltration more effectively than naproxen. ATB\u2010346 was as effective as naproxen in adjuvant\u2010induced arthritis in rats, with a more rapid onset of activity. Unlike naproxen, ATB\u2010346 did not elevate blood pressure in hypertensive rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and implications:\u2002<\/jats:bold>\n                    ATB\u2010346 exhibits anti\u2010inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity.\n                  <\/jats:p>","DOI":"10.1111\/j.1476-5381.2009.00611.x","type":"journal-article","created":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T09:47:52Z","timestamp":1265017672000},"page":"1236-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":191,"title":["Markedly reduced toxicity of a hydrogen sulphide\u2010releasing derivative of naproxen (ATB\u2010346)"],"prefix":"10.1111","volume":"159","author":[{"given":"John 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