{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:30:17Z","timestamp":1789907417905,"version":"4.0.1"},"reference-count":139,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,5,11]],"date-time":"2011-05-11T00:00:00Z","timestamp":1305072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Coordinated electrical activity in the heart is supported by gap junction channels located at the intercalated discs of cardiomyocytes. Impaired gap junctional communication between neighbouring cardiomyocytes contributes to the development of re\u2010entry arrhythmias after myocardial ischaemia. Current antiarrhythmic therapy is hampered by a lack of efficiency and side effects, creating the need for a new generation of drugs. In this review, we focus on compounds that increase gap junctional communication, thereby increasing the conduction velocity and decreasing the risk of arrhythmias. Some of these compounds also inhibit connexin 43 (Cx43) hemichannels, thereby limiting adenosine triphosphate loss and volume overload following ischaemia\/reperfusion, thus potentially increasing the survival of cardiomyocytes. The compounds discussed in this review are: (i) antiarrythmic peptide (AAP), AAP10, ZP123; (ii) GAP\u2010134; (iii) RXP\u2010E; and (vi) the Cx mimetic peptides Gap 26 and Gap 27. None of these compounds have effects on Na<jats:sup>+<\/jats:sup>, Ca<jats:sup>2+<\/jats:sup> and K<jats:sup>+<\/jats:sup> channels, and therefore have no proarrhythmic activity associated with currently available antiarrhythmic drugs. GAP\u2010134, RXP\u2010E, Gap 26 and Gap 27 are pharmalogical agents with a favorable clinical safety profile, as already confirmed in phase I clinical trials for GAP\u2010134. These agents show an excellent promise for treatment of arrhythmias in patients with ischaemic cardiomyopathy.<\/jats:p>","DOI":"10.1111\/j.1476-5381.2011.01244.x","type":"journal-article","created":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T09:14:28Z","timestamp":1296033268000},"page":"469-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Pharmacological modulation of connexin\u2010formed channels in cardiac pathophysiology"],"prefix":"10.1111","volume":"163","author":[{"given":"Elke","family":"De Vuyst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Boengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Antoons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin R.","family":"Sipido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Leybaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,11]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00099-5"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.28.3332"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.5.40"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.31.612"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.03.005"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.8.656"},{"key":"e_1_2_18_8_1","first-page":"1112","article-title":"The \u2018Sicilian Gambit\u2019. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. The Task Force of the Working Group on Arrhythmias of the European Society of Cardiology","volume":"12","author":"Bigger JT","year":"1991","journal-title":"Eur Heart J"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.014"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10365"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(02)00180-X"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2115"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603372103"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706429"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm801558d"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092566"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh2101.098612"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.6.H1911"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.12.005"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.4.1754"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000231407.61683.05"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01956042"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.07.002"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.138"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.196"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00113-4"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092570"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241093"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419060109080734"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/cac.10.4-6.371.378"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0473-1"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.3.293"},{"key":"e_1_2_18_33_1","unstructured":"DorianP ZhongJ SoPSS DebickiD HennanJK(2005).Increasing gap junction conductance with ZP123 improves defibrillation success in experimental cardiac arrest. InAmerican Heart Association. pp.II\u2013115. Abstract No. 637. Dallas Texas USA Circulation."},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr0708922"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000227572.45891.2c"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.02.007"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000101926.43759.10"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000250174.31269.70"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0290606"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060175"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.007"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3579"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00441-8"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(98)00129-6"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00419-3"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(00)00056-9"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp028"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.45.1007"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/15419060500514135"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.40687.x"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000200990.31611.6e"},{"key":"e_1_2_18_52_1","first-page":"S839","volume-title":"Circulation","author":"Hawat G","year":"2009"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0849-6"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.096933"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248409340779"},{"key":"e_1_2_18_56_1","first-page":"487","volume-title":"Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease","author":"Issa Z","year":"2009"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021102131603"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01197.x"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1414"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0317-4"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2010.487866"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5048-07.2008"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.12.029"},{"key":"e_1_2_18_64_1","first-page":"A698","article-title":"The antiarrhytmic peptide HPP\u20105 reduces APD90 dispersion and prevents ventricular fibrillation in isolated perfused rabbit hearts","volume":"14","author":"Kjolbye AL","year":"2000","journal-title":"FASEB J"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200211000-00015"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.052258"},{"key":"e_1_2_18_67_1","first-page":"292","article-title":"Maintenance of intercellular coupling by ZP123 suppresses arrhytmogenic discordant alternans","volume":"108","author":"Kjolbye AL","year":"2005","journal-title":"Circulation"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00123.x"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2003"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.61.2.271"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.35.3928"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1220"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051922"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2131"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03089"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.790212"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.5.547"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.179069"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/cac.10.4-6.251.257"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(02)00102-3"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/2210"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605048200"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(79)90376-6"},{"key":"e_1_2_18_84_1","first-page":"286","article-title":"Effects of cyclic AMP on the function of the cardiac gap junction during hypoxia","volume":"11","author":"Matsumura K","year":"2006","journal-title":"Exp Clin Cardiol"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp157"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00441.2003"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01115.2006"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00879.2009"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)89679-3"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005031"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.5.1357"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200001000-00009"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.01.023"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00448.2008"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90291-J"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq129"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70318-7"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.4.988"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032292"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.07.014"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1101.091193"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-0668X(02)00809-6"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.087742"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.095587"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016702.86180.F6"},{"key":"e_1_2_18_106_1","first-page":"1","article-title":"Pharmacological enhancement of cardiac gap junction coupling prevents arrhythmias in canine LQT2 model","author":"Quan XQ","year":"2009","journal-title":"Cell Commun Adhes"},{"key":"e_1_2_18_107_1","first-page":"825","article-title":"[The effects of antiarrhythmic peptide AAP10 on ventricular arrhythmias in rabbits with healed myocardial infarction]","volume":"34","author":"Ren Y","year":"2006","journal-title":"Zhonghua Xin Xue Guan Bing Zhi [Chin J Cardiovasc Dis]"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00439.2005"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.150102"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40927"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.6.H2563"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00023-1"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00344.x"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276982"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb02603.x"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn133"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000225911.24228.9c"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00022.2007"},{"key":"e_1_2_18_119_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01074.2002"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.10.3051"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-007-9035-y"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20082319"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200707060"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.103.039230"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1080\/15419060600631375"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.1.13.989"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.48.12.2026"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-007-9072-6"},{"key":"e_1_2_18_129_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000144805.11519.1e"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.12.278"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.12.092"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.200576"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.06.028"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.12.1103"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0918fje"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-008-0771-7"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2002.076"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02329.x"},{"key":"e_1_2_18_139_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543780903020308"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2334"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.2011.01244.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.2011.01244.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:46:18Z","timestamp":1697424378000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.2011.01244.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,11]]},"references-count":139,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1476-5381.2011.01244.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01244.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,11]]},"assertion":[{"value":"2011-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}