{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:19:19Z","timestamp":1791893959910,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T00:00:00Z","timestamp":1319414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p><jats:bold>BACKGROUND AND PURPOSE<\/jats:bold> The endocannabinoid system appears to play a pivotal role in mediating the rewarding and reinforcing effects of nicotine. Recent studies have shown that the inhibition of fatty acid amide hydrolase (FAAH) attenuates reinstatement of nicotine\u2010seeking induced by nicotine priming and nicotine\u2010associated cues. FAAH hydrolyses the endogenous endocannabinoid anandamide, as well as other non\u2010cannabinoid ligands such as oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). As OEA and PEA can attenuate both nicotine\u2010taking and nicotine\u2010seeking behaviour, the specific role of anandamide remains unclear. In this study, we have tested the selective anadamide uptake inhibitor, VDM11, which elevates anandamide levels without affecting levels of OEA\/PEA, on nicotine\u2010taking and nicotine\u2010seeking behaviour.<\/jats:p><jats:p><jats:bold>EXPERIMENTAL APPROACH<\/jats:bold> We used a nicotine intravenous self\u2010administration model in rats to assess the effect of VDM11, given i.p., on nicotine taking using fixed and progressive ratio schedules of reinforcement as well as on reinstatement of nicotine\u2010seeking induced by nicotine priming and nicotine\u2010associated cues.<\/jats:p><jats:p><jats:bold>KEY RESULTS<\/jats:bold> VDM11 did not affect levels of responding for nicotine under fixed\u2010ratio and progressive\u2010ratio schedules of reinforcement. In contrast, VDM11 dose\u2010dependently attenuated reinstatement of nicotine\u2010seeking behaviour induced by nicotine\u2010associated cues and nicotine priming.<\/jats:p><jats:p><jats:bold>CONCLUSIONS AND IMPLICATIONS<\/jats:bold> These results indicate that ligands elevating anandamide levels could have therapeutic value for preventing relapse into nicotine\u2010seeking behaviour and should be tested in humans trying to quit smoking.<\/jats:p>","DOI":"10.1111\/j.1476-5381.2011.01440.x","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T11:48:45Z","timestamp":1303127325000},"page":"1652-1660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake"],"prefix":"10.1111","volume":"164","author":[{"given":"Islam","family":"Gamaleddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail","family":"Guranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Le Foll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,24]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"S1","article-title":"Guide to Receptors and Channels (GRAC), 4th edn.","volume":"158","author":"Alexander SPH","year":"2009","journal-title":"Br J Pharmacol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.105221"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-09-03401.2000"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3510817"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/374272a0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301061"},{"issue":"3","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3310\/hta13suppl3-03","article-title":"Rimonabant for the treatment of overweight and obese people","volume":"13","author":"Burch J","year":"2009","journal-title":"Health Technol Assess"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90134-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05665.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00589894"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02082-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.06.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470919"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_0505"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01283-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0752434.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.5.2.241"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.078980"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.16.7656"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300407"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1569-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.029"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.62"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.03.048"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00314.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061029898"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122196999"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709991064"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.100792"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.077974"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00113.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1506-7"},{"key":"e_1_2_8_34_1","unstructured":"Le FollB ChatterjeeM Lev\u2010RanS BarnesC GamaleddinI PushparajAet\u2003al. 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