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In the present review, we explore the mechanisms underlying the physiological and pharmacological actions of GLP\u20101 and amylin agonism. Despite their similarities (e.g. both molecular classes slow gastric emptying, decrease glucagon and inhibit food intake), there are important distinctions between the central and\/or peripheral pathways that mediate their effects on glycaemia and energy balance. We suggest that understanding the similarities and differences between these molecules holds important implications for the development of novel, combination\u2010based therapies, which are increasingly the norm for diabetes\/metabolic disease. Finally, the future of GLP\u20101\u2010 and amylin agonist\u2010based therapeutics is discussed.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>LINKED ARTICLES<\/jats:bold>\n                    This article is part of a themed section on Secretin Family (Class B) G Protein\u2010Coupled Receptors. To view the other articles in this section visit\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/bph.2012.166.issue-1\">http:\/\/dx.doi.org\/10.1111\/bph.2012.166.issue\u20101<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1111\/j.1476-5381.2011.01537.x","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T03:13:27Z","timestamp":1308107607000},"page":"121-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["GLP\u20101R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities"],"prefix":"10.1111","volume":"166","author":[{"given":"Jonathan D","family":"Roth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary 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