{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:41:19Z","timestamp":1794008479424,"version":"4.8.0"},"reference-count":172,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T00:00:00Z","timestamp":1323993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>\n                    The drug efflux pump P\u2010glycoprotein (P\u2010gp) plays an important role in the function of the blood\u2013brain barrier by selectively extruding certain endogenous and exogenous molecules, thus limiting the ability of its substrates to reach the brain. Emerging evidence suggests that P\u2010gp may restrict the uptake of several antidepressants into the brain, thus contributing to the poor success rate of current antidepressant therapies. Despite some inconsistency in the literature, clinical investigations of potential associations between functional single nucleotide polymorphisms in\n                    <jats:italic>ABCB1<\/jats:italic>\n                    , the gene which encodes P\u2010gp, and antidepressant response have highlighted a potential link between P\u2010gp function and treatment\u2010resistant depression (TRD). Therefore, co\u2010administration of P\u2010gp inhibitors with antidepressants to patients who are refractory to antidepressant therapy may represent a novel therapeutic approach in the management of TRD. Furthermore, certain antidepressants inhibit P\u2010gp\n                    <jats:italic>in vitro<\/jats:italic>\n                    , and it has been hypothesized that inhibition of P\u2010gp by such antidepressant drugs may play a role in their therapeutic action. The present review summarizes the available\n                    <jats:italic>in vitro<\/jats:italic>\n                    ,\n                    <jats:italic>in vivo<\/jats:italic>\n                    and clinical data pertaining to interactions between antidepressant drugs and P\u2010gp, and discusses the potential relevance of these interactions in the treatment of depression.\n                  <\/jats:p>","DOI":"10.1111\/j.1476-5381.2011.01557.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T14:49:37Z","timestamp":1309445377000},"page":"289-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":206,"title":["Interactions between antidepressants and P\u2010glycoprotein at the blood\u2013brain barrier: clinical significance of\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    findings"],"prefix":"10.1111","volume":"165","author":[{"given":"Fionn E","family":"O'Brien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G","family":"Dinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan T","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Cryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168750"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09522"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2011.04.001"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.12.016"},{"key":"e_1_2_18_8_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0026-895X(24)05623-2","article-title":"Pregnane X receptor up\u2010regulation of P\u2010glycoprotein expression and transport function at the blood\u2010brain barrier","volume":"66","author":"Bauer B","year":"2004","journal-title":"Mol Pharmacol"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.029512"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.16"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384844"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900253n"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00116-0"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.40.3.648"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019504"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.3.292"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.00967.x"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.114164"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.114164"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/447655a"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60046-5"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2033"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1008"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900743c"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.2.695"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1825"},{"key":"e_1_2_18_27_1","doi-asserted-by":"crossref","DOI":"10.1159\/isbn.978-3-8055-9606-0","volume-title":"Depression: From Psychopathology to Pharmacotherapy","author":"Cryan JF","year":"2010"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05720.x"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500196"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.4.1652"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e328315a561"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.001230"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027011"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-006-0664-4"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9000226"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.820"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.667"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1515\/DMDI.2006.21.3-4.139"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357043969"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.03.017"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00231-2"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.017434"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318038d835"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31817d6f5d"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62031089.x"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc706"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881104042831"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790320076010"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.2.4"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199701)19:1<13::AID-GLIA2>3.0.CO;2-B"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.01.007"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071701"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3473"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00159-7"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics2020258"},{"key":"e_1_2_18_56_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0022-3565(24)39030-5","article-title":"Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P\u2010glycoprotein modulation","volume":"295","author":"Ibrahim S","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.95"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200103000-00008"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)00219-5"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/325253a0"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.129196"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(76)90160-7"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319427"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9135-x"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.138"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.04.004"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2148-5"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.6.8213"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1750251"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1314.048"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.09.003"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.117412"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135308"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.11.009"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709009894"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109349840"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318181b865"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300280"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00801.x"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.066605"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.03.004"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181d2ef42"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.3.1.81"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32833db216"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00050.x"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000912"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1728"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.04.028"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0041"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0554"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.03.008"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.4.5917"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90054-H"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.03.018"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.03.003"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300257"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00491.2007"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70326-5"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2995"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.12.023"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.09.010"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.1.3"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.10.013"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.067"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.06.006"},{"key":"e_1_2_18_106_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1124\/mol.52.4.571","article-title":"Steroid\u2010independent translocation of the glucocorticoid receptor by the antidepressant desipramine","volume":"52","author":"Pariante CM","year":"1997","journal-title":"Mol Pharmacol"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704368"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300195"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705357"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2003.10.009"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2007.20.6.1141496"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.010"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001872"},{"key":"e_1_2_18_114_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3410\/B1-23","article-title":"The ABCB1 transporter gene and antidepressant response","volume":"1","author":"Peters EJ","year":"2009","journal-title":"F1000 Biol Rep"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656561003614781"},{"key":"e_1_2_18_116_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0022-3565(24)29270-3","article-title":"Rational use of in vitro p\u2010glycoprotein assays in drug discovery","volume":"299","author":"Polli JW","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.34.1.207"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0345-0"},{"key":"e_1_2_18_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500099"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01461-4"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi990064q"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi700330b"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20717"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32833b593a"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42909-2"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2004.11.003"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00085-4"},{"key":"e_1_2_18_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90212-7"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118214"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4028"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm021012t"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00122.x"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.1.105"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021986"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1676"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)00287-F"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010609"},{"key":"e_1_2_18_139_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802610792927997"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00020-8"},{"key":"e_1_2_18_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1984"},{"key":"e_1_2_18_142_1","doi-asserted-by":"publisher","DOI":"10.1177\/37.2.2463300"},{"key":"e_1_2_18_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00158-X"},{"key":"e_1_2_18_144_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.1.28"},{"key":"e_1_2_18_145_1","doi-asserted-by":"crossref","first-page":"24248","DOI":"10.1016\/S0021-9258(18)35757-0","article-title":"Human P\u2010glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone","volume":"267","author":"Ueda K","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_18_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(03)00022-0"},{"key":"e_1_2_18_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00095-0"},{"key":"e_1_2_18_148_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2002.00836.x"},{"key":"e_1_2_18_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00074-X"},{"key":"e_1_2_18_150_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881104047278"},{"key":"e_1_2_18_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.10.005"},{"key":"e_1_2_18_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.11.017"},{"key":"e_1_2_18_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0714-8"},{"key":"e_1_2_18_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.54"},{"key":"e_1_2_18_155_1","first-page":"209","article-title":"Reversal of multidrug resistance by amitriptyline in vitro","volume":"16","author":"Varga A","year":"1996","journal-title":"Anticancer Res"},{"key":"e_1_2_18_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.10.012"},{"key":"e_1_2_18_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940130302"},{"key":"e_1_2_18_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0209-y"},{"key":"e_1_2_18_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0437-9"},{"key":"e_1_2_18_160_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.231"},{"key":"e_1_2_18_161_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916184"},{"key":"e_1_2_18_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301076"},{"key":"e_1_2_18_163_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046532"},{"key":"e_1_2_18_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(02)00200-8"},{"key":"e_1_2_18_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-008-0658-9"},{"key":"e_1_2_18_166_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0022-3565(24)38809-3","article-title":"In vitro substrate identification studies for P\u2010glycoprotein\u2010mediated transport: species difference and predictability of in vivo results","volume":"296","author":"Yamazaki M","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_18_167_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31802bb20d"},{"key":"e_1_2_18_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301389"},{"key":"e_1_2_18_169_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110445"},{"key":"e_1_2_18_170_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp050095h"},{"key":"e_1_2_18_171_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498250701867889"},{"key":"e_1_2_18_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301181"},{"key":"e_1_2_18_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.2011.01557.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.2011.01557.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:09:35Z","timestamp":1741277375000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.2011.01557.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,16]]},"references-count":172,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1476-5381.2011.01557.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01557.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,16]]},"assertion":[{"value":"2011-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}