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Structurally related \u03c9\u2010conotoxins bind directly to and selectively inhibit neuronal (N)\u2010type voltage\u2010gated calcium channels (VGCCs) of nociceptive primary afferent neurones. Among these, \u03c9\u2010conotoxin MVIIA (Prialt) is approved by the Food and Drug Administration (FDA) as an alternative intrathecal analgesic for the management of chronic intractable pain, particularly in patients refractory to opioids. A series of newly discovered \u03c9\u2010conotoxins from <jats:italic>Conus catus<\/jats:italic>, including CVID\u2013F, are potent and selective antagonists of N\u2010type VGCCs. In spinal cord slices, these peptides reversibly inhibit excitatory synaptic transmission between primary afferents and dorsal horn superficial lamina neurones, and in the rat partial sciatic nerve ligation model of neuropathic pain, significantly reduce allodynic behaviour. 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