{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:51:00Z","timestamp":1768344660170,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T00:00:00Z","timestamp":1340755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>BACKGROUND AND PURPOSE<\/jats:bold> Airway sensory nerves play a key role in respiratory cough, dyspnoea, airway hyper\u2010responsiveness (AHR), all fundamental features of airway diseases [asthma and chronic obstructive pulmonary disease (COPD)\u2003]. Vagally mediated airway reflexes such as cough, bronchoconstriction and chest tightness originate from stimulation of airway sensory nerve endings. The transient receptor potential vanilloid 1 receptor (TRPV1) is present on peripheral terminals of airway sensory nerves and modulation of its activity represents a potential target for the pharmacological therapy of AHR in airway disease.<\/jats:p><jats:p><jats:bold>EXPERIMENTAL APPROACH<\/jats:bold> As guinea pig models can provide some of the essential features of asthma, including AHR, we have established the model with some classical pharmacological agents and examined the effect of the TRPV1 antagonists, SB\u2010705498 and PF\u201004065463 on AHR to histamine evoked by ovalbumin (OA) in unanaesthetized sensitized guinea pigs restrained in a double chamber plethysmograph. Specific airway conductance (sGaw) derived from the airflow was calculated as a percentage of change from baseline.<\/jats:p><jats:p><jats:bold>KEY RESULTS<\/jats:bold> Cetirizine and salbutamol significantly inhibited OA\u2010evoked bronchoconstriction [sGaw area under the curve (AUC): 70 and 78%, respectively]. Atropine, SB\u2010705498 and PF\u201004065463 significantly inhibited OA\u2010evoked AHR to histamine in unanaesthetized, OA\u2010sensitized guinea pigs (sGaw AUC: 94%, 57% and 73%, respectively). Furthermore, this effect was not related to antagonism of histamine's activity.<\/jats:p><jats:p><jats:bold>CONCLUSION AND IMPLICATIONS<\/jats:bold> These data suggest that TRPV1 receptors located on airway sensory nerves are important in the development of AHR and that modulation of TRPV1\u2010receptor activity represents a potential target for the pharmacological therapy of AHR in airway disease.<\/jats:p>","DOI":"10.1111\/j.1476-5381.2012.01891.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T11:18:45Z","timestamp":1328786325000},"page":"1822-1832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Inhibition of airway hyper\u2010responsiveness by TRPV1 antagonists (SB\u2010705498 and PF\u201004065463) in the unanaesthetized, ovalbumin\u2010sensitized guinea pig"],"prefix":"10.1111","volume":"166","author":[{"given":"I","family":"Delescluse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Mace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.12.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01649_1.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.127258"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.01109s4567"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/35082088"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00209.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.063"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00748.2002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)01999-5"},{"key":"e_1_2_8_12_1","unstructured":"GunthorpeMJ HannanSL JermanJC EgertonJ SmartD RamiHKet\u2003al. 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