{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:11Z","timestamp":1787585951696,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>A wide variety of beneficial effects have been attributed to curcumin, a major polyphenol from the golden spice<jats:italic>Curcuma longa<\/jats:italic>known as turmeric, including amelioration of severe complications of type 2 diabetes such as hepatic fibrosis, retinopathy, neuropathy and nephropathy. In the present issue of<jats:italic>BJP<\/jats:italic>, Lin and colleagues reveal new mechanisms by which curcumin inhibits the activation of hepatic stellate cells<jats:italic>in vitro<\/jats:italic>, a hallmark of non\u2010alcoholic steatohepatitis and hepatic fibrogenesis associated with type 2 diabetes mellitus. They demonstrated that curcumin suppresses the advanced glycation end\u2010products (AGEs)\u2010mediated induction of the receptor for AGEs (<jats:italic>RAGE<\/jats:italic>) gene expression by increasing PPAR\u03b3 activity and stimulating<jats:italic>de novo<\/jats:italic>synthesis of glutathione. As a result, downstream elements of RAGE\u2010activated pathways are inhibited, which prevents oxidative stress, inflammation and hepatic stellate cell activation. This report suggests that curcumin may have potential as an anti\u2010fibrotic agent in type 2 diabetes and opens the door to the evaluation of curcumin therapeutic effects in liver conditions of different aetiology and in other disorders linked to the impairment of PPAR\u03b3 activity, such as obesity and atherosclerosis.<\/jats:p><jats:p><jats:bold>LINKED ARTICLE<\/jats:bold>This article is a commentary on Lin<jats:italic>et\u2003al<\/jats:italic>., pp. 2212\u20132227 of this issue. To view this paper visit<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/j.1476-5381.2012.01910.x\">http:\/\/dx.doi.org\/10.1111\/j.1476\u20105381.2012.01910.x<\/jats:ext-link><\/jats:p>","DOI":"10.1111\/j.1476-5381.2012.01959.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T12:41:42Z","timestamp":1332852102000},"page":"2209-2211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus \u2013 insights into its mechanisms of action"],"prefix":"10.1111","volume":"166","author":[{"given":"B","family":"Stefanska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.012809.104755"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16064567"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411002055"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3181c08081"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707542"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-7-38"},{"key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.14712\/fb2010056050195","article-title":"Reversal of hypermethylation and reactivation of the RARbeta2 gene by natural compounds in cervical cancer cell lines","volume":"56","author":"Jha AK","year":"2010","journal-title":"Folia Biol (Praha)"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021771823"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00261.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01910.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.12.041"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014229"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0409230"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01590.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-57"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32832e0af3"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00956.x"},{"key":"e_1_2_4_19_1","unstructured":"World Health Organization Media Centre(2011). 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