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This study was designed to assess the contribution of different nAChR subtypes to the behavioural and neurochemical effects of chronic cocaine treatment.<\/jats:p><jats:p><jats:bold>EXPERIMENTAL APPROACH<\/jats:bold> Cocaine (15\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, i.p.) was administered to male C57BL\/6J mice in a chronic \u2018binge\u2019 paradigm, with and without the coadministration of the \u03b17 preferring nAChR antagonist methyllycaconitine (MLA; 5\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, i.p.) or the \u03b22* nAChR antagonist dihydro\u2010\u03b2\u2010erythroidine (DH\u03b2E; 2\u2003mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, i.p.). Quantitative autoradiography was used to examine the effect of cocaine exposure on \u03b17 and \u03b14\u03b22* nAChRs, and on the high\u2010affinity choline transporter.<\/jats:p><jats:p><jats:bold>KEY RESULTS<\/jats:bold> MLA+cocaine administration induced an intense self\u2010grooming behaviour, indicating a likely role for \u03b17 nAChRs in modulating this anxiogenic, compulsive\u2010like effect of cocaine. In the major island of Calleja, a key area of action for neuroleptics, MLA+cocaine reduced choline transporter binding compared with cocaine (with or without DH\u03b2E) administration. DH\u03b2E treatment prevented the induction of stereotypy sensitisation to cocaine but prolonged locomotor sensitisation, implicating heteromeric \u03b22* nAChRs in the neuroadaptations mediating cocaine\u2010induced behavioural sensitisation. \u2018Binge\u2019 cocaine treatment region\u2010specifically increased \u03b14\u03b22* nAChR binding in the midbrain dopaminergic regions: ventral tegmental area and substantia nigra pars compacta.<\/jats:p><jats:p><jats:bold>CONCLUSIONS AND IMPLICATIONS<\/jats:bold> We have shown a differential, subtype\u2010selective, contribution of nAChRs to the behavioural and neurochemical sequelae of chronic cocaine administration. These data support the clinical utility of targeting specific nAChR subtypes for the alleviation of cocaine\u2010abuse symptomatology.<\/jats:p>","DOI":"10.1111\/j.1476-5381.2012.02023.x","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T06:44:36Z","timestamp":1336545876000},"page":"450-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The stereotypy\u2010inducing and OCD\u2010like effects of chronic \u2018binge\u2019 cocaine are modulated by distinct subtypes of nicotinic acetylcholine 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