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To date, only two specific P\/Q\u2010type blockers are known: both are peptides deriving from the spider venom of<jats:italic>Agelenopsis aperta<\/jats:italic>, \u03c9\u2010agatoxins. Other peptidic calcium channel blockers with activity at P\/Q channels are available, albeit with less selectivity. A number of low molecular weight compounds modulate P\/Q\u2010type currents with different characteristics, and some exhibit a peculiar bidirectional pattern of modulation. Interestingly, there are a number of therapeutics in clinical use, which also show P\/Q channel activity. Because selectivity as well as the exact mode of action is different between all P\/Q\u2010type channel modulators, the interpretation of clinical and experimental data is complicated and needs a comprehensive understanding of their target profile. The situation is further complicated by the fact that information on potency varies vastly in the literature, which may be the result of different experimental systems, conditions or the splice variants of the P\/Q channel. This review attempts to provide a comprehensive overview of the compounds available that affect the P\/Q\u2010type channel and should help with the interpretation of results of<jats:italic>in vitro<\/jats:italic>experiments and animal models. It also aims to explain some clinical observations by implementing current knowledge about P\/Q channel modulation of therapeutically used non\u2010selective drugs. 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