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In the past 30 years, the voltage\u2010gated calcium channels (VGCCs) have been recognized as potential targets for analgesic development. Although the majority of the research has been focused on Ca<jats:sub>v<\/jats:sub>2.2 in particular, other VGCC subtypes such as Ca<jats:sub>v<\/jats:sub>3.2 have recently come to the forefront of analgesic research. Venom peptides from marine cone snails have been proven to be a valuable tool in neuroscience, playing a major role in the identification and characterization of VGCC subtypes and producing the first conotoxin\u2010based drug on the market, the \u03c9\u2010conotoxin, ziconotide. This peptide potently and selectively inhibits Ca<jats:sub>v<\/jats:sub>2.2, resulting in analgesia in chronic pain states. However, this drug is only available via intrathecal administration, and adverse effects and a narrow therapeutic window have limited its use in the clinic. Other Ca<jats:sub>v<\/jats:sub>2.2 inhibitors are currently in development and offer the promise of an improved route of administration and safety profile. 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