{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:12:49Z","timestamp":1764781969015,"version":"3.40.4"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Recreational users report that mephedrone has similar psychoactive effects to 3,4\u2010methylenedioxymethamphetamine (<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>).<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>induces well\u2010characterized changes in body temperature due to complex monoaminergic effects on central thermoregulation, peripheral blood flow and thermogenesis, but there are little preclinical data on the acute effects of mephedrone or other synthetic cathinones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>The acute effects of cathinone, methcathinone and mephedrone on rectal and tail temperature were examined in individually housed rats, with<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>included for comparison. Rats were killed 2\u2009h post\u2010injection and brain regions were collected for quantification of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, dopamine and major metabolites. Further studies examined the impact of selected \u03b1\u2010adrenoceptor and dopamine receptor antagonists on mephedrone\u2010induced changes in rectal temperature and plasma catecholamines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>At normal room temperature,<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>caused sustained decreases in rectal and tail temperature. Mephedrone caused a transient decrease in rectal temperature, which was enhanced by \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor and dopamine<jats:styled-content style=\"fixed-case\">D<jats:sub>1<\/jats:sub><\/jats:styled-content>receptor blockade, and a prolonged decrease in tail temperature. Cathinone and methcathinone caused sustained increases in rectal temperature.<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>decreased 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>and\/or 5\u2010hydroxyindoleacetic acid (5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content>) content in several brain regions and reduced striatal homovanillic acid (<jats:styled-content style=\"fixed-case\">HVA<\/jats:styled-content>) levels, whereas cathinone and methcathinone increased striatal<jats:styled-content style=\"fixed-case\">HVA<\/jats:styled-content>and 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content>. Cathinone elevated striatal and hypothalamic 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>. Mephedrone elevated plasma noradrenaline levels, an effect prevented by \u03b1\u2010adrenoceptor and dopamine receptor antagonists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>and cathinones have different effects on thermoregulation, and their acute effects on brain monoamines also differ. These findings suggest that the adverse effects of cathinones in humans cannot be extrapolated from previous observations on<jats:styled-content style=\"fixed-case\">MDMA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1476-5381.2012.02236.x","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T14:36:57Z","timestamp":1349707017000},"page":"966-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Differential effects of cathinone compounds and<scp>MDMA<\/scp>on body temperature in the rat, and pharmacological characterization of mephedrone\u2010induced hypothermia"],"prefix":"10.1111","volume":"168","author":[{"given":"SE","family":"Shortall","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AR","family":"Green","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KM","family":"Swift","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KCF","family":"Fone","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MV","family":"King","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"ACMD(2010).Consideration of the cathinones. Available at:http:\/\/www.homeoffice.gov.uk\/acmd1\/acmd\u2010cathinones\u2010report\u20102010(accessed 23\/9\/2010).","DOI":"10.1299\/jsmeacmd.2010.5.Cover1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01649_1.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.028506"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.304"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706688"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.05.050"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1986.tb04571.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.11.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0815-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb12846.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.312"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00722.x"},{"key":"e_1_2_8_14_1","unstructured":"EMCDDA(2011).Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances. Available at:http:\/\/www.emcdda.europa.eu\/html.cfm\/index116639EN.html(accessed October 2011)."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)80419-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.12.033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0801(199905)13:3<209::AID-BMC820>3.0.CO;2-Z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(91)90288-D"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.3.3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706318"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01819.x"},{"key":"e_1_2_8_22_1","first-page":"2769","article-title":"Mephedrone \u2013 Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance","volume":"106","author":"Gustavsson D","year":"2009","journal-title":"Lakartidningen"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0022-3565(25)12381-1","article-title":"Methcathinone: an initial study of its effects on monoaminergic systems","volume":"276","author":"Gygi MP","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0022-3565(24)37162-9","article-title":"Role of endogenous dopamine in the neurochemical deficits induced by methcathinone","volume":"283","author":"Gygi MP","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.184119"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110370984"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.188425"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.78"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036476"},{"key":"e_1_2_8_30_1","first-page":"917","article-title":"The pharmacology and toxicology of \u2018ecstasy\u2019 (MDMA) and related drugs","volume":"165","author":"Kalant H","year":"2001","journal-title":"Can Med Assoc J"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01499.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1334-1"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2010.11.001"},{"key":"e_1_2_8_35_1","first-page":"A45","article-title":"Cathinone: the behavioural and neurotoxic effects in Lister Hooded rodents","volume":"25","author":"Macerola AE","year":"2011","journal-title":"J Psychopharmacol"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00873.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/anatox\/35.3.188"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704442"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.10.010"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3636-5"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.07.003"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0022-3565(25)24086-1","article-title":"Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4\u2010methylenedioxymethamphetamine","volume":"245","author":"Nash JF","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.05.033"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.08.012"},{"key":"e_1_2_8_45_1","doi-asserted-by":"crossref","first-page":"8648","DOI":"10.1523\/JNEUROSCI.21-21-08648.2001","article-title":"Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4\u2010methylenedioxymethamphetamine (ecstasy) in conscious rabbits","volume":"21","author":"Pedersen NP","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(90)90041-O"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb14963.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(97)70351-2"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1921-9"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2070-x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.07.005"},{"key":"e_1_2_8_52_1","first-page":"A38","article-title":"Behavioural and neurochemical responses to chronic intermittent mephedrone administration in the rat","volume":"25","author":"Shortall SE","year":"2011","journal-title":"J Psychopharmacol"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.09.005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02145.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.044982"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90494-3"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00660.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.12.014"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000435"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03502.x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03130.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.531021"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2010.092288"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs107"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.2012.02236.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.2012.02236.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:41:18Z","timestamp":1744263678000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.2012.02236.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1476-5381.2012.02236.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02236.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"type":"print","value":"0007-1188"},{"type":"electronic","value":"1476-5381"}],"subject":[],"published":{"date-parts":[[2013,1,24]]},"assertion":[{"value":"2012-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}