{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:31:52Z","timestamp":1792416712348,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T00:00:00Z","timestamp":1303084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Safety and efficacy of pegylated liposome encapsulated doxorubicin (PL\u2010DOX) was compared with free doxorubicin as an adjuvant monotherapy in dogs with splenic haemangiosarcoma after splenectomy in a randomized prospective clinical trial. A total of 17 dogs in each group were treated. No significant difference in survival between the two treatments was found. The calculated median overall survival time for the 34 dogs was 166 days [95% confidence interval (CI) 148\u2013184]. The \u00bd year and one\u2010year survival was 41.2% (95% CI 24.8\u201356.9) and 22.7% (95% CI 9.9\u201337.4), respectively. In dogs treated with PL\u2010DOX, a desquamating dermatitis like palmar\u2010plantar erythrodysesthesia (PPES) was seen in two dogs, while three other dogs showed anaphylactic reactions. Cardiotoxicity was not seen in either treatment groups.<\/jats:p>","DOI":"10.1111\/j.1476-5829.2011.00266.x","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:54:29Z","timestamp":1303174469000},"page":"283-289","source":"Crossref","is-referenced-by-count":29,"title":["A randomized controlled study into the efficacy and toxicity of pegylated liposome encapsulated doxorubicin as an adjuvant therapy in dogs with splenic haemangiosarcoma"],"prefix":"10.1111","volume":"9","author":[{"given":"E.","family":"Teske","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Rutteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kirpenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hirschberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,18]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"167.","volume-title":"NCI Monograph 54.","author":"Priester WA","year":"1980"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2460\/javma.1988.193.06.706","article-title":"Epidemiologic, clinic, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985).","volume":"193","author":"Prymak C","year":"1988","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_4_2","first-page":"56","article-title":"Canine hemangiosarcoma: Retrospective analysis of 104 cases.","volume":"186","author":"Brown NO","year":"1985","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(78)90012-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.129.18.408"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00085.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1989.tb03092.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.231.10.1550"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-5-417"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb02262.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb00943.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03019.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01033.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb02247.x"},{"key":"e_1_2_5_16_2","first-page":"1165","article-title":"Liposome\u2010encapsulated muramyl tripeptide phosphatidyl\u2010ethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: A randomized multi\u2010institutional clinical trial.","volume":"1","author":"Vail D","year":"1995","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_5_17_2","first-page":"17","article-title":"Comparison of the cardiotoxic effects of liposomal doxorubicin (TLC D\u201099) versus free doxorubicin in beagle dogs.","volume":"7","author":"Kanter PM","year":"1993","journal-title":"In Vivo"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1992.tb03156.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018907715905"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199700544-00005"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342050-00002"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11460"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.08.010"},{"key":"e_1_2_5_24_2","first-page":"2796","article-title":"Initial clinical (Phase I) trial of TLC D\u201099 (doxorubicin encapsulated in liposomes).","volume":"53","author":"Cowens JW","year":"1993","journal-title":"Cancer Research"},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0022-3565(24)38244-8","article-title":"Reduction of the cardiotoxicity of doxorubicin in rabbits and dogs by encapsulation in long\u2010circulating, pegylated liposomes.","volume":"289","author":"Working PK","year":"1999","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2004.0053b.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/08982109409037065"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01958.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.1996.111"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050591"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1191\/096032799678839347"},{"key":"e_1_2_5_32_2","first-page":"1567","article-title":"Efficacy of pyridoxine to ameliorate the cutaneous toxicity associated with doxorubicin containing pegylated (Stealth) liposomes: a randomized, double\u2010blind clinical trial using a canine model.","volume":"4","author":"Vail DM","year":"1998","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_5_33_2","volume-title":"The Principles and Practice of Clinical Trials","author":"Gorringe JAL.","year":"1970"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.11.010"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5829.2011.00266.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5829.2011.00266.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T04:11:24Z","timestamp":1741147884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5829.2011.00266.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,18]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1111\/j.1476-5829.2011.00266.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5829.2011.00266.x","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,18]]}}}