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Eleven blood borne biomarkers were examined for their worth as early tumour biomarkers. During 2.5 years, five dogs with early DHS were identified; four of these by diagnostic imaging. No dogs developed symptomatic DHS without being detected within 6 months of the screening programme. Only serum ferritin showed potential as a blood borne marker of the disease. Median survival times for the dogs with early DHS were 226 days. Screening programmes every 6 months for Bernese Mountain dogs over 4 years of age including diagnostic imaging and ferritin measurements may identify early DHS.<\/jats:p>","DOI":"10.1111\/j.1476-5829.2011.00285.x","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T11:40:05Z","timestamp":1313062805000},"page":"124-134","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs"],"prefix":"10.1111","volume":"10","author":[{"given":"L. N.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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