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Few reports have described AML\u2010M7 in dogs using flow cytometry. This clinical case points out the utility of flow cytometry in the characterization of AML\u2010M7 in a 3\u2010year\u2010old German Shepherd dog. Flow cytometry investigation has established megakaryocytic lineage involvement by showing the presence of two megakaryocyte\/platelet associated antigens (CD9 and CD61). In human medicine CD9 may be used as a platelet and megakaryocyte marker. There is an evidence of cross\u2010reactivity of human anti\u2010CD9 monoclonal antibody with canine samples. To our knowledge, the use of CD9 has never been described before, for this purpose in the dog.<\/jats:p>","DOI":"10.1111\/j.1476-5829.2011.00290.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T06:08:40Z","timestamp":1314857320000},"page":"312-318","source":"Crossref","is-referenced-by-count":11,"title":["Use of CD9 and CD61 for the characterization of AML\u2010M7 by flow cytometry in a dog<sup>*<\/sup>"],"prefix":"10.1111","volume":"10","author":[{"given":"F.","family":"Valentini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gavazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lubas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,31]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830350115"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0902-4441.2003.00207.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00081-4"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.06.013"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2008.00099.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00185.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00189.x"},{"key":"e_1_2_4_9_2","first-page":"911","article-title":"Chemotherapy in canine acute megakaryoblastic leukemia: a case report and review of the literature.","volume":"23","author":"Willmann M","year":"2009","journal-title":"In Vivo"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2460\/javma.1991.199.03.359","article-title":"Cytosine arabinoside chemotherapy for acute megakaryocytic leukemia in a cat.","volume":"199","author":"Hamilton TA","year":"1991","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063870601800311"},{"key":"e_1_2_4_12_2","first-page":"679","article-title":"Uber einem Fall von akuten Megakaryoblasten leukamie, zugleich einige Bemerkungen zum Problem der akuten Lukamie.","volume":"118","author":"Von Boros J","year":"1931","journal-title":"Zeitschrift fur klinische Medizin"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589002700314"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-3-460"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509075307"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1996.tb00958.x"},{"key":"e_1_2_4_17_2","first-page":"9","article-title":"Megakaryozyten leukose beim hund [Megakaryocytic leukosis in a dog].","volume":"17","author":"Rudolph R","year":"1972","journal-title":"Kleintier Praxis"},{"key":"e_1_2_4_18_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2460\/javma.1986.188.05.529","article-title":"Platelet dysplasia associated with megakaryoblastic leukemia in a dog.","volume":"188","author":"Cain GR","year":"1986","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200622"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2007.tb00227.x"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50055-0"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00010.x"},{"key":"e_1_2_4_23_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2460\/javma.1995.207.02.194","article-title":"Megakaryoblastic leukemia in a dog.","volume":"207","author":"Pucheu\u2010Haston CM","year":"1995","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1991.tb00571.x"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-620"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.5326\/0460327"},{"key":"e_1_2_4_27_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0021-9258(18)52410-8","article-title":"Molecular cloning of the CD9 antigen. 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