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In this study, we analysed whether the two above\u2010mentioned resveratrol oligomers were able to inhibit the growth of the canine glioblastoma cell line D\u2010<jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> and the canine histiocytic sarcoma cell line <jats:styled-content style=\"fixed-case\">DH82<\/jats:styled-content>, compared their potency to inhibit tumour cell growth with that of resveratrol and determined whether the induction of apoptosis via caspase 9 and 3\/7 activation underlies the tumour cell growth\u2010inhibiting effect of hopeaphenol and r2\u2010viniferin. Vineatrol<jats:sup>\u00ae<\/jats:sup>30, resveratrol, hopeaphenol and r2\u2010viniferin inhibited the growth of D\u2010<jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DH82<\/jats:styled-content> cells in a concentration\u2010dependent manner, whereby hopeaphenol and r2\u2010viniferin were more potent than resveratrol itself in inhibiting the growth of the canine tumour cell lines. Moreover, the anti\u2010proliferative effect of both resveratrol oligomers in D\u2010<jats:styled-content style=\"fixed-case\">GBM<\/jats:styled-content> cells is based on their capacity to induce caspase 9 and 3\/7 activation.<\/jats:p>","DOI":"10.1111\/j.1476-5829.2012.00349.x","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T05:11:38Z","timestamp":1344575498000},"page":"149-159","source":"Crossref","is-referenced-by-count":26,"title":["The growth of the canine glioblastoma cell\u00a0line D\u2010<scp>GBM<\/scp> and the canine histiocytic sarcoma cell line <scp>DH82<\/scp> is inhibited by the resveratrol oligomers hopeaphenol and\u00a0r2\u2010viniferin"],"prefix":"10.1111","volume":"12","author":[{"given":"M. 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