{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:36:45Z","timestamp":1791193005271,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":1444,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","hpbonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["HPB"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1111\/j.1477-2574.2012.00587.x","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T06:38:22Z","timestamp":1350369502000},"page":"71-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Segmental and lobar administration of drug\u2010eluting beads delivering irinotecan leads to tumour destruction: a case\u2013control series"],"prefix":"10.1016","volume":"15","author":[{"given":"Robert P.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Z.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Terlizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"O'Grady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Koelblinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"St\u00e4ttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stremitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gruenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J.","family":"Poston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/00000658-200206000-00002","article-title":"Trends in longterm survival following liver resection for hepatic colorectal metastases","volume":"235","author":"Choti","year":"2002","journal-title":"Ann Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0015","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1200\/JCO.1994.12.7.1491","article-title":"Survival benefit of repeat liver resections for recurrent colorectal metastases: 143 cases. Association Francaise de Chirurgie","volume":"12","author":"Nordlinger","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0020","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/BF03215859","article-title":"Analysis of predictive factors for recurrence after hepatectomy for colorectal liver metastases","volume":"25","author":"Yamada","year":"2001","journal-title":"World J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0025","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s00268-001-0069-5","article-title":"Genetic markers of survival and liver recurrence after resection of liver metastases from colorectal cancer","volume":"25","author":"Crowe","year":"2001","journal-title":"World J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0030","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1007\/s00268-002-6231-x","article-title":"Hepatic resection for colorectal metastases: can preoperative scoring predict patient outcome?","volume":"26","author":"Mala","year":"2002","journal-title":"World J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0035","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1046\/j.0007-1323.2001.01821.x","article-title":"Resection rate and effect of postoperative chemotherapy on survival after surgery for colorectal liver metastases","volume":"88","author":"Figueras","year":"2001","journal-title":"Br J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0040","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/BF02234142","article-title":"Hepatic resection for colorectal metastases: analysis of prognostic factors","volume":"42","author":"Ambiru","year":"1999","journal-title":"Dis Colon Rectum"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0045","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/BF02053981","article-title":"Resection of liver metastases from colorectal cancer: are there any truly significant clinical prognosticators?","volume":"39","author":"Wang","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0050","first-page":"1136","article-title":"Late results justify resection for multiple hepatic metastases from colorectal cancer","volume":"84","author":"Rees","year":"1997","journal-title":"Br J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0055","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1001\/archsurg.1996.01430150100019","article-title":"Patient selection for hepatic resection of colorectal metastases","volume":"131","author":"Wanebo","year":"1996","journal-title":"Arch Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0060","first-page":"360","article-title":"Resection of liver metastases in colorectal cancer \u2013 competitive analysis of treatment results in synchronous versus metachronous metastases","volume":"16","author":"Schlag","year":"1990","journal-title":"Eur J Surg Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0065","first-page":"13","article-title":"Indicators of prognosis after hepatic resection for colorectal secondaries","volume":"110","author":"Scheele","year":"1991","journal-title":"Surgery"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0002-9610(98)00303-1","article-title":"Is carcinoembryonic antigen useful in the follow\u2010up management of patients with colorectal liver metastases?","volume":"177","author":"Bakalakos","year":"1999","journal-title":"Am J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0075","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/annonc\/mdi246","article-title":"Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates","volume":"16","author":"Folprecht","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10434-001-0347-3","article-title":"Five\u2010year survival following hepatic resection after neoadjuvant therapy for non\u2010resectable colorectal","volume":"8","author":"Adam","year":"2001","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0085","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1200\/JCO.2004.05.113","article-title":"FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study","volume":"22","author":"Tournigand","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0090","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1200\/JCO.2006.09.0928","volume":"25","author":"Falcone","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0095","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0140-6736(08)60455-9","article-title":"Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC intergroup trial 40983): a randomized controlled trial","volume":"371","author":"Nordlinger","year":"2008","journal-title":"Lancet"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0100","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2012.30.15_suppl.3508","article-title":"EORTC liver metastases intergroup randomized Phase III study 40983: longterm survival results","volume":"30","author":"Nordlinger","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0105","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.ejca.2006.04.012","article-title":"Towards a pan\u2010European consensus on the treatment of patients with colorectal liver metastases","volume":"42","author":"Van Cutsem","year":"2006","journal-title":"Eur J Cancer"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0110","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1200\/JCO.2008.20.1301","article-title":"Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma","volume":"27","author":"Kemeny","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jamcollsurg.2005.03.019","article-title":"Technical complications and durability of hepatic artery infusion pumps for unresectable colorectal liver metastases: an institutional experience of 544 consecutive cases","volume":"201","author":"Allen","year":"2005","journal-title":"J Am Coll Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0120","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2012.30.15_suppl.3613","article-title":"Neoadjuvant treatment of colorectal liver metastases (CRLM) with drug\u2010eluting beads transarterial chemoembolization (DEBIRI\u2010TACE): a multi\u2010institute Phase II study in resectable metastases","volume":"30","author":"Jones","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0125","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/bjs.8844","article-title":"Contrast\u2010enhanced intraoperative ultrasonography using perfluorobutane microbubbles for the enumeration of colorectal liver metastases","volume":"99","author":"Takahashi","year":"2012","journal-title":"Br J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/annonc\/mdl386","article-title":"Importance of histological tumour response assessment in predicting the outcome in patients with colorectal liver metastases treated with neoadjuvant chemotherapy followed by liver surgery","volume":"18","author":"Rubbia\u2010Brandt","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0135","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1245\/s10434-010-1288-5","article-title":"Hepatic intra\u2010arterial injection of drug\u2010eluting bead, irinotecan (DEBIRI) in unresectable colorectal liver metastases refractory to systemic chemotherapy: results of multi\u2010institutional study","volume":"18","author":"Martin","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0140","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s11605-012-1892-8","article-title":"Irinotecan drug\u2010eluting beads in the treatment of chemo\u2010na\u00efve unresectable colorectal liver metastasis with concomitant systemic fluorouracil and oxaliplatin: results of pharmacokinetics and Phase I trial","volume":"16","author":"Martin","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0145","first-page":"1387","article-title":"Intra\u2010arterial infusion of irinotecan\u2010loaded drug\u2010eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a Phase III study","volume":"32","author":"Fiorentini","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0150","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1200\/JCO.2008.17.5299","article-title":"Pathologic response to preoperative chemotherapy: a new outcome endpoint after resection of hepatic colorectal metastases","volume":"26","author":"Blazer","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0155","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1245\/s10434-012-2335-1","article-title":"Pathologic response to preoperative chemotherapy in colorectal liver metastases: fibrosis, not necrosis, predicts outcome","volume":"19","author":"Poultsides","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0160","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/bjs.8667","article-title":"Systematic review and meta\u2010analysis of follow\u2010up after hepatectomy for colorectal liver metastases","volume":"99","author":"Jones","year":"2012","journal-title":"Br J Surg"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0165","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1245\/ASO.2004.08.019","article-title":"Local recurrences after intraoperative radiofrequency ablation of liver metastases: a comparative study with anatomic and wedge resections","volume":"11","author":"Elias","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0170","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1200\/JCO.2006.05.8727","article-title":"Complete response of colorectal liver metastases after chemotherapy: does it mean cure?","volume":"24","author":"Benoist","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1111\/j.1477-2574.2012.00587.x_bb0175","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1007\/s11605-007-0218-8","article-title":"Chemotherapy\u2010induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response","volume":"11","author":"Tan","year":"2007","journal-title":"J Gastrointest Surg"}],"container-title":["HPB"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X15313150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1365182X15313150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T23:57:03Z","timestamp":1761263823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1365182X15313150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1365182X15313150"],"URL":"https:\/\/doi.org\/10.1111\/j.1477-2574.2012.00587.x","relation":{},"ISSN":["1365-182X"],"issn-type":[{"value":"1365-182X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Segmental and lobar administration of drug\u2010eluting beads delivering irinotecan leads to tumour destruction: a case\u2013control series","name":"articletitle","label":"Article Title"},{"value":"HPB","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1477-2574.2012.00587.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 International Hepato-Pancreato-Biliary Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}