{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:52:42Z","timestamp":1790099562207,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T00:00:00Z","timestamp":1069891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Extrahepatic portal venous obstruction (EHPVO) developing due to thrombotic occlusion of the portal vein in children is generally considered a benign disease. Whether hepatic dysfunction develops in these patients in the absence of a gastrointestinal bleed has not been well studied.<\/jats:p><jats:p><jats:bold>Materials and methods: <\/jats:bold> Forty\u2010three patients with EHPVO who had not bled in the last 3 months were studied. Patients were divided into those with (group I) or without ascites (group II). Matched cirrhotic patients with ascites (group III) served as controls. Clinical, biochemical, ultrasonographic, and histopathological evaluation was carried out. Portal biliopathy was assessed in five patients in group I and in 12 patients in group II by cholangiography.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Of 43 EHPVO patients, ascites was seen in nine (21%) patients (group I). Thirty\u2010four patients had no ascites (group II). Serum ALT (54\u00b124 vs. 34\u00b110 IU\/l, <jats:italic>P<\/jats:italic>&lt;0.01), albumin (3.2\u00b10.3 vs. 3.7\u00b10.4 g\/dl, <jats:italic>P<\/jats:italic>&lt;0.01), and prothrombin time difference (9.0\u00b14.5 vs. 2.4\u00b11.9\u2003s, <jats:italic>P<\/jats:italic>&lt;0.05) were deranged in patients in group I compared with group II. Patients in group I were 4 years older, and the duration of portal hypertension was longer than in group II (11.5 vs. 5.6 year, <jats:italic>P<\/jats:italic>&lt;0.05). Portal biliopathy changes were significantly more severe in group I than in group II patients. Ascites was high gradient in all the patients in group I and the serum\u2010ascitic albumin gradient was comparable between groups I and III. None of the EHPVO patients, but four cirrhotic patients, developed spontaneous bacterial peritonitis during a follow\u2010up of 11\u00b14 months.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Hepatic dysfunction in the form of ascites and deranged liver functions is not uncommon in patients with EHPVO, more so in patients with prolonged portal hypertension. Based on our data it would be worthwhile to study whether prolonged portal vein thrombosis in EHPVO patients could lead to progressive liver disease.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2003.00879.x","type":"journal-article","created":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T16:15:33Z","timestamp":1069949733000},"page":"434-439","source":"Crossref","is-referenced-by-count":94,"title":["Hepatic dysfunction in patients with extrahepatic portal venous obstruction"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"Rangari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007502"},{"key":"e_1_2_5_3_2","first-page":"13","volume-title":"Idiopathic Portal Hypertension","author":"Koshy A.","year":"1983"},{"key":"e_1_2_5_4_2","first-page":"78","article-title":"Follow\u2010up of patients after variceal eradication","volume":"204","author":"Sarin S K","year":"1986","journal-title":"A comparison of patients with cirrhosis, non-cirrhotic portal fibrosis and extrahepatic obstruction"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150210"},{"key":"e_1_2_5_6_2","first-page":"627","article-title":"The etiology, presentation and natural history of extrahepatic portal venous obstruction","volume":"48","author":"Webb L J","year":"1979","journal-title":"Q J Med"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0016-5085(80)90081-5","article-title":"Immune function in patients with extra\u2010hepatic portal venous obstruction and effect of splenomegaly","volume":"79","author":"Webb L J","year":"1980","journal-title":"Gastroenterology"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(66)80008-9"},{"key":"e_1_2_5_9_2","volume-title":"The Hepatic Circulation and Portal Hypertension","author":"Clatworthy H W.","year":"1974"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196510000-00006"},{"key":"e_1_2_5_11_2","first-page":"27","volume-title":"Portal Hypertension: Pathophysiology and Treatment","author":"Sarin S K.","year":"1994"},{"issue":"2","key":"e_1_2_5_12_2","article-title":"Monoethylene glycine xylidide (MEGX). A sensitive non\u2010invasive method to differentiate NCPF and Child's A chronic liver disease","volume":"16","author":"Misra A","year":"1997","journal-title":"Ind J Gastroenterol"},{"issue":"2","key":"e_1_2_5_13_2","article-title":"Comparative study of portal biliopathy in patients with portal hypertension due to different etiologies","volume":"16","author":"Chandra R","year":"1997","journal-title":"Ind J Gastroenterol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2540"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90687-X"},{"key":"e_1_2_5_16_2","first-page":"88","article-title":"Liver regeneration following porta caval shunt","volume":"52","author":"Fisher B","year":"1962","journal-title":"Surgery"},{"key":"e_1_2_5_17_2","first-page":"669","article-title":"Hepatotrophic factors in liver growth and atrophy","volume":"66","author":"Rozga J, Jeppsson B","year":"1985","journal-title":"Br J Exp Path"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199711000-00006"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80005-1"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170510"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23206"},{"issue":"2","key":"e_1_2_5_22_2","article-title":"Progression of portal biliopathy in extrahepatic portal venous obstruction","volume":"18","author":"Chawla A","year":"1999","journal-title":"Ind J Gastroenterol"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1478-3231.2003.00879.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1478-3231.2003.00879.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T14:36:32Z","timestamp":1697207792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1478-3231.2003.00879.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,27]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1111\/j.1478-3231.2003.00879.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1478-3231.2003.00879.x","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,27]]}}}