{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:54:39Z","timestamp":1766588079868},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T00:00:00Z","timestamp":1101427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Abstract: Background: <\/jats:bold> Alcoholic hepatitis (AH) is associated with dysregulated inflammatory and immune responses. interleukin\u201018 (IL\u201018), described as \u03b3 interferon (\u03b3IFN)\u2010inducible factor, and its natural antagonist, IL\u201018 binding protein (IL\u201018 BP), has not been fully studied in patients with AH. Thus, our aim was: (i) to determine <jats:italic>plasma<\/jats:italic> values of IL\u201018, IL\u201018 BP, \u03b3IFN, and tumor necrosis factor \u03b1 (TNF)\u2010\u03b1 in patients hospitalized for biopsy\u2010proven AH; (ii) to correlate these cytokines with the severity of AH, as assessed by Maddrey's discriminant function (DF), the degree of liver failure using the Child\u2013Pugh score and blood neutrophils; (iii) to compare cytokines values in survivors and non\u2010survivors.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Cytokines were measured using specific immunoassays within 7 days of admission. The diagnosis of AH was based on histology in all cases. We studied 43 cirrhotic patients with a Maddrey's DF\u226532 (severe AH), 29 patients with a score &lt;32 (non\u2010severe AH), 12 patients with abstinent alcoholic cirrhosis, and 10 healthy subjects.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> IL\u201018 and TNF\u03b1 were increased in severe AH as compared with healthy subjects. <jats:italic>Plasma<\/jats:italic> IL\u201018 BP was elevated in patients with severe and non\u2010severe AH as compared with healthy subjects. \u03b3IFN did not differ between groups. In patients with severe and non\u2010severe AH, IL\u201018, IL\u201018 BP, TNF\u03b1, but not \u03b3IFN, were positively correlated to DF and Child\u2013Pugh score. Neither IL\u201018 nor IL\u201018 BP correlated to TNF\u03b1. Patients who died (<jats:italic>n<\/jats:italic>=10) during the hospitalization had higher IL\u201018 BP and TNF\u03b1 at admission as compared with survivors (322 [172\u2013504] vs 222 [109\u2013441]\u2003ng\/ml; 7.5 [2.2\u201317.3] vs 3 [0.6\u201320]\u2003pg\/ml, <jats:italic>P<\/jats:italic>&lt;0.01, respectively).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> In cirrhotic patients with AH, IL\u201018, IL\u201018 BP, and TNF\u03b1 correlate to the hepatitis severity and to the degree of liver failure. High IL\u201018 BP and TNF\u03b1 at hospital admission in non\u2010survivors suggest it may be of prognostic value.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2004.0967.x","type":"journal-article","created":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T13:36:39Z","timestamp":1101476199000},"page":"582-587","source":"Crossref","is-referenced-by-count":19,"title":["Circulating concentrations of interleukin\u201018, interleukin\u201018 binding protein, and \u03b3 interferon in patients with alcoholic hepatitis"],"prefix":"10.1111","volume":"24","author":[{"given":"Laurent","family":"Spahr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ir\u00e8ne","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange","family":"Bresson\u2010Hadni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rubbia\u2010Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Guler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Olleros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolande","family":"Chvatchko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Hadengue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,26]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"251S","article-title":"Mechanisms of alcoholic liver disease","volume":"25","author":"Neumann M G","year":"2001","journal-title":"cytokines"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0650rev"},{"key":"e_1_2_8_4_2","first-page":"448","article-title":"Combination of steroids with infliximab or placebo in severe alcoholic hepatitis","volume":"37","author":"Spahr L","year":"2002","journal-title":"a randomized controlled pilot study"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00442-7"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70354-9"},{"key":"e_1_2_8_7_2","first-page":"41","article-title":"Circulating and tissue levels of the neutrophil chemotaxin Interleukin\u20108 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration","volume":"18","author":"Sheron N","year":"1993","journal-title":"Hepatology"},{"key":"e_1_2_8_8_2","first-page":"23","article-title":"Cytokine levels in acute alcoholic hepatitis","volume":"39","author":"Rodriguez\u2010Rodriguez E","year":"1995","journal-title":"a sequential study"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432007"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.6.779"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017418.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655202320378347"},{"key":"e_1_2_8_13_2","first-page":"707","article-title":"Alcoholic liver disease","volume":"1","author":"International Group.","year":"1981","journal-title":"morphological manifestations. 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