{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:07:13Z","timestamp":1790539633755,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T00:00:00Z","timestamp":1121299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Abstract: Background\/Aims: <\/jats:bold> The aim of this study was to elucidate the incidence and clinical manifestations of portal vein thrombosis (PVT) in patients with idiopathic portal hypertension (IPH) in Japan during long\u2010term follow\u2010up.<\/jats:p><jats:p><jats:bold>Patients and Methods: <\/jats:bold> Twenty\u2010two patients with IPH were examined for PVT by sonography during a follow\u2010up of 12\u00b16 years. Clinical manifestations and patient outcome related to PVT were studied. Seventy patients with liver cirrhosis were examined by sonography as an incidence control of thrombosis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Nine IPH patients had portal thrombosis (9\/22, 41%), a higher incidence than in liver cirrhosis patients (7\/70, 10%). Those with thrombosis showed ascites, marked hypersplenism, and low serum albumin. Four patients with thrombosis died. Patients without thrombosis showed less clinical problems after long\u2010term follow\u2010up. Plasma antithrombin III and protein C activity decreased in almost half of the patients. However, there were no differences in these parameters between patients with and without thrombosis.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> In Japan, IPH patients had a high incidence of portal thrombosis, a significant factor for poor prognosis. Whether the management of PVT contributes to an improvement of a clinical course of IPH or not should be clarified in further study.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2005.01151.x","type":"journal-article","created":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T08:00:44Z","timestamp":1126598444000},"page":"978-983","source":"Crossref","is-referenced-by-count":45,"title":["Study of portal vein thrombosis in patients with idiopathic portal hypertension in Japan"],"prefix":"10.1111","volume":"25","author":[{"given":"Shoichi","family":"Matsutani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Akiike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Yoshizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Okugawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fukuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Saisho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,14]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"535","article-title":"Portal 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