{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:09:07Z","timestamp":1764587347507},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T00:00:00Z","timestamp":1144627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Abstract: Introduction: <\/jats:bold>  <jats:italic>In<\/jats:italic>\n          <jats:italic>situ<\/jats:italic> hypothermic perfusion (HP) can be applied to attenuate ischemia and reperfusion (I\/R) injury during liver resection under total vascular exclusion (TVE). This study examines the protective effect of cooling by HP at 20 and 28\u00b0C as compared with no HP during TVE in a porcine liver I\/R model.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Twenty\u2010one pigs underwent 60\u2003min TVE of the liver followed by 24\u2003h reperfusion. HP was performed via the portal vein using ringerlactate solution of 4\u00b0C. Pigs were assigned to three groups: TVE without HP (no\u2010HP, <jats:italic>n<\/jats:italic>=9), TVE with HP at 28\u00b0C (HP\u201028, <jats:italic>n<\/jats:italic>=6) and TVE with HP at 20\u00b0C (HP\u201020, <jats:italic>n<\/jats:italic>=6).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Perfusion volumes during TVE were 5.1\u00b10.5 and 17.3\u00b11.7\u2003l in HP\u201028 and HP\u201020, respectively (<jats:italic>P<\/jats:italic>&lt;0.05). Aspartate aminotransferase (AST) after 24\u2003h reperfusion was 1172\u00b1440\u2003U\/l in no\u2010HP as compared with 223\u00b169 and 180\u00b122\u2003U\/l in HP\u201028 and HP\u201020, respectively (<jats:italic>P<\/jats:italic>&lt;0.05). No differences in liver function or histopathology were found between the HP\u201028 and HP\u201020 groups.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> HP at 20\u00b0C is equally effective in preserving liver function and preventing hepatocellular injury under TVE as compared with HP at 28\u00b0C. HP at 28\u00b0C is advised, because of the lesser perfusion volume necessary for cooling of the liver.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01248.x","type":"journal-article","created":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T16:29:24Z","timestamp":1144859364000},"page":"486-493","source":"Crossref","is-referenced-by-count":14,"title":["Liver protection by hypothermic perfusion at different temperatures during total vascular exclusion"],"prefix":"10.1111","volume":"26","author":[{"given":"Sander","family":"Dinant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne Q.","family":"Van Veen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik J.","family":"Roseboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arl\u00e8ne K.","family":"Van 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