{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:18:20Z","timestamp":1793171900625,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T00:00:00Z","timestamp":1148515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Abstract: Background and aims: <\/jats:bold> Endotoxin\u2010responsive monocytes\/macrophages (CD14\u2010positive) are potential sources of profibrogenic factors. The aims of this study were to determine (1) whether hepatic CD14\u2010positive cells are present in various forms of chronic liver disease, and (2) the relationship between CD14\u2010positive cells, myofibroblasts, and fibrosis in these diseases.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Liver specimens from control subjects (<jats:italic>n<\/jats:italic>=12) and those with primary biliary cirrhosis (<jats:italic>n<\/jats:italic>=18), chronic hepatitis C (<jats:italic>n<\/jats:italic>=13), or nonalcoholic steatohepatitis (<jats:italic>n<\/jats:italic>=13) were immunostained for CD14, CD68, and \u03b1\u2010smooth muscle actin (SMA) and the number of cells expressing these antigens was determined. Fibrosis and inflammation were also assessed.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The total number of hepatic CD68\u2010positive cells was similar in diseased and control livers. The number of CD14\u2010positive cells was increased in advanced fibrosis in primary biliary cirrhosis and hepatitis C but not in nonalcoholic steatohepatitis. The number of CD14\u2010positive cells was also increased in hepatitis C specimens with high inflammatory activity. CD14\u2010positive cells were often associated with \u03b1\u2010SMA\u2010positive myofibroblasts in fibrous septa.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The number of hepatic CD14\u2010positive cells is increased in advanced fibrosis in subjects with primary biliary cirrhosis and hepatitis C but not in nonalcoholic steatohepatitis. In primary biliary cirrhosis and hepatitis C, CD14\u2010positive macrophages are found in close proximity to fibrous septa and myofibroblasts. In hepatitis C, an increased number of CD14\u2010positive cells are associated with high inflammatory activity.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01255.x","type":"journal-article","created":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T09:05:56Z","timestamp":1148547956000},"page":"559-565","source":"Crossref","is-referenced-by-count":20,"title":["Differential findings for CD14\u2010positive hepatic monocytes\/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis"],"prefix":"10.1111","volume":"26","author":[{"given":"Katherine L.","family":"Leicester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Olynyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Brunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00429-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17555"},{"key":"e_1_2_6_4_2","first-page":"459","article-title":"Proinflammatory blood monocytes","volume":"41","author":"Scherberich J E.","year":"2003","journal-title":"main effector and target cells in systemic and renal disease; 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