{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:13Z","timestamp":1790030053848,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T00:00:00Z","timestamp":1146182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Abstract: Background: <\/jats:bold> The benefit of surveillance of hepatocellular carcinoma (HCC) for patients with hepatitis C virus (HCV) infection, in terms of long\u2010term survival, has not yet been established.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> A total of 384 consecutive anti\u2010HCV\u2010positive HCC patients admitted to our hospital between January 1991 and October 2003 were enrolled. Patients were categorized into two groups, a surveillance group (182 patients) and a non\u2010surveillance group (202 patients), according to tumor detection in a surveillance program based on periodical examination via ultrasound sonography and alpha fetoprotein determination at 6\u2010month intervals, and their survival rates were compared.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Although there were no significant differences in age and Child\u2013Pugh classes between the two groups, the surveillance group exhibited a smaller tumor size (19 vs. 35\u2003mm) and a higher incidence of single HCC (67% vs. 46%), compared with the non\u2010surveillance group (each, <jats:italic>P<\/jats:italic>&lt;0.001). The cumulative survival rate in the surveillance group was higher than that in the non\u2010surveillance group (5 years survival, 46% vs. 32%, <jats:italic>P<\/jats:italic>&lt;0.001). When the survival after correction of the lead\u2010time bias in the surveillance group was analyzed according to the Child\u2013Pugh classification, the surveillance program was found to have had a favorable outcome in Child\u2013Pugh class A patients, but not in Child\u2013Pugh class B\/C patients.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> HCC surveillance for patients with HCV infection can lead to discovery of tumors at an early stage, especially in Child\u2013Pugh class A, resulting in a favorable outcome.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01270.x","type":"journal-article","created":{"date-parts":[[2006,4,29]],"date-time":"2006-04-29T04:23:28Z","timestamp":1146284608000},"page":"543-551","source":"Crossref","is-referenced-by-count":45,"title":["Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival"],"prefix":"10.1111","volume":"26","author":[{"given":"Hironori","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nouso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Kobashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouta","family":"Iwado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohsaku","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shiratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78179-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130303"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160508"},{"key":"e_1_2_5_5_2","first-page":"47","article-title":"A multivariate analysis of risk factors for hepatocellular carcinogenesis","volume":"18","author":"Ikeda K","year":"1993","journal-title":"a prospective observation of 795 patients with viral and alcoholic cirrhosis"},{"key":"e_1_2_5_6_2","first-page":"1029","article-title":"Screening for hepatocellular carcinoma in patients with Child's A cirrhosis","volume":"21","author":"Cottone M","year":"1994","journal-title":"an 8-year prospective study by ultrasound and alphafetoprotein"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941101)74:9<2442::AID-CNCR2820740909>3.0.CO;2-#"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960901)78:5<977::AID-CNCR6>3.0.CO;2-9"},{"key":"e_1_2_5_9_2","first-page":"174","article-title":"Interferon therapy reduces the risk for hepatocellular carcinoma","volume":"131","author":"Yoshida H","year":"1999","journal-title":"national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. 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