{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:47:41Z","timestamp":1763070461442},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T00:00:00Z","timestamp":1151452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Abstract: Background\/Aim: <\/jats:bold> Hepatorenal syndrome (HRS) is associated with a poor prognosis. The incidence and prognostic impact of kidney dysfunction due to other causes in cirrhotic patients are less well known. The current study prospectively evaluated the incidence and the prognostic relevance of different etiologies of kidney failure in cirrhotic patients.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Eighty\u2010eight consecutive patients with cirrhosis and serum creatinine \u22651.5\u2003mg\/dl were enrolled. The etiologies of kidney dysfunction were analyzed, and prognostic factors including Model for End\u2010Stage Liver Disease (MELD) score were evaluated in a multivariate Cox model.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> HRS was present in 35 (40%) patients (15 HRS 1, 20 HRS 2), followed by renal parenchymal disease (23%), drug\u2010induced kidney dysfunction (19%) and prerenal failure due to bleeding or infections (15%). HRS patients had a significantly higher MELD score and shorter survival. In addition to the MELD score, only HRS 1 was independently predictive for survival. HRS 2 patients had a similar outcome as patients with non\u2010HRS kidney dysfunction.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> In patients with cirrhosis and renal failure, hepatorenal syndrome is associated with a worse prognosis than kidney dysfunction due to other conditions but only HRS type 1 has independent prognostic relevance in addition to the MELD score in these patients.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01302.x","type":"journal-article","created":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T10:48:14Z","timestamp":1151491694000},"page":"834-839","source":"Crossref","is-referenced-by-count":45,"title":["Prognostic factors for patients with cirrhosis and kidney dysfunction in the era of MELD: results of a prospective study"],"prefix":"10.1111","volume":"26","author":[{"given":"Michael","family":"Schepke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Appenrodt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Heller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Zielinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman","family":"Sauerbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14903-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90031-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"e_1_2_6_5_2","first-page":"1282","article-title":"MELD score and clinical type predict prognosis in hepatorenal syndrome","volume":"41","author":"Allesandria C","year":"2005","journal-title":"relevance to transplantation"},{"issue":"1","key":"e_1_2_6_6_2","first-page":"S69","article-title":"Ascites and hepatorenal syndrome in cirrhosis","volume":"38","author":"Arroyo V","year":"2003","journal-title":"pathophysiological basis of therapy and current management"},{"key":"e_1_2_6_7_2","first-page":"923","article-title":"Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome","volume":"122","author":"Moreau R","year":"2002","journal-title":"a retrospective multicenter study"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50016"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07515.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50084"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035021"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071294"},{"issue":"61","key":"e_1_2_6_14_2","first-page":"77","article-title":"Prognostic significance of renal dysfunction in cirrhosis","volume":"52","author":"Gines P","year":"1997","journal-title":"Kidney Int"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00011-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20284"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1478-3231.2006.01302.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1478-3231.2006.01302.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:20:28Z","timestamp":1697095228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1478-3231.2006.01302.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,28]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1478-3231.2006.01302.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1478-3231.2006.01302.x","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,28]]}}}