{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:02:59Z","timestamp":1789840979841,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T00:00:00Z","timestamp":1154563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract: Objectives:<\/jats:bold>\n                    A non\u2010invasive, simple and non\u2010expensive test to predict cirrhosis would be highly desirable. The aspartate aminotransferase\/alanine aminotransferase (AST\/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To test whether the AST\/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    The study consisted of 160 patients. In 126 patients, we had clinical and laboratory data at the time of diagnosis and follow\u2010up with outcome: liver\u2010related death, liver transplantation and survival. In 121 patients, we had laboratory data and liver histology.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    We found that the AST\/ALT ratio was significantly higher in cirrhotic patients than in non\u2010cirrhotic patients. A high AST\/ALT ratio was significantly associated with esophageal varices and ascites. In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The AST\/ALT ratio seems to be of clinical value as a hint to the diagnosis of cirrhosis in patients with PBC but not as a prognostic factor.\n                  <\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01304.x","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T04:28:20Z","timestamp":1154579300000},"page":"840-845","source":"Crossref","is-referenced-by-count":173,"title":["The AST\/ALT ratio as an indicator of cirrhosis in patients with PBC"],"prefix":"10.1111","volume":"26","author":[{"given":"Helena","family":"Nyblom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Aldenborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Almer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,3]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"14","article-title":"Liver transplantation in the Nordic countries, 1982\u20131998","volume":"34","author":"Bjoro K","year":"1999","journal-title":"changes of indications and improving results"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20933"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00465-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.009"},{"key":"e_1_2_6_6_2","first-page":"477","article-title":"Practices of liver biopsy in France","volume":"32","author":"Cadranel J F","year":"2000","journal-title":"results of a prospective nationwide survey. 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