{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:58:42Z","timestamp":1768787922525,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Cirrhosis is associated with intestinal barrier failure, related in part to enterocytes oxidative damage via xanthine oxidase overactivity. Experimentally, allopurinol, a xanthine oxidase inhibitor, reduces enterocytes' damage and bacterial translocation.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> To assess the short\u2010term effects of allopurinol on intestinal permeability, oxidative stress and endotoxin\u2010dependent cytokines in patients with cirrhosis.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Nineteen patients with cirrhosis, in a stable condition (age: 56 years; Child A\/B\/C: 6\/7\/6; ascites: 12; alcoholic cirrhosis: 16\/19; abstinence &gt;2 weeks), were included. At baseline and day 10 of allopurinol 400\u2003mg\/day, intestinal permeability [lactulose\/mannitol (Lac\/Man) ratio test], oxidative stress (serum malondialdehyde), as well as TNF\u2010soluble receptor\u20101, IL\u20106 and lipopolysaccharide\u2010binding protein (which reflects exposition to endotoxin) were measured.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Malondialdehyde decreased significantly (\u221223%, <jats:italic>P<\/jats:italic>&lt;0.05), whereas no effects were seen on intestinal permeability and the endotoxin\u2010associated systemic inflammatory response. At baseline, portal pressure correlated to the Lac\/Man ratio (<jats:italic>r<\/jats:italic>=0.55, <jats:italic>P<\/jats:italic>&lt;0.02). At day 10, changes in malondialdehyde correlated to changes in the Lac\/Man ratio (<jats:italic>r<\/jats:italic>=0.51, <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> A 10\u2010day course of allopurinol in patients with cirrhosis is associated with a significant reduction in oxidative stress but no effect on intestinal permeability and inflammatory markers. Whether intestinal damage in cirrhosis can be accessible to antioxidant therapy requires further study.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01382.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T17:23:10Z","timestamp":1165425790000},"page":"54-60","source":"Crossref","is-referenced-by-count":38,"title":["Allopurinol, oxidative stress and intestinal permeability in patients with cirrhosis: an open\u2010label pilot 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