{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:25:17Z","timestamp":1759047917166},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T00:00:00Z","timestamp":1170892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\/Aims: <\/jats:bold> Severe involvement of central and\/or peripheral nervous system is a rare complication of hepatitis C virus (HCV)\u2010related cryoglobulinaemia.<\/jats:p><jats:p><jats:bold>Method: <\/jats:bold> Four patients with HCV\u2010related type II\/III cryoglobulinaemia (three males with genotype 1, one female with genotype 3) who presented with severe sensory\u2013motor polyneuropathy, one with central nervous system involvement as well, were treated with pegylated IFNa\u20102b 1.5\u2003\u03bcg\/kg\/week and ribavirin 10.6\u2003mg\/kg\/daily for 48 weeks. Neurological evaluation involved detailed clinical motor and sensory scores\/scales and neurophysiological studies before and after treatment.<\/jats:p><jats:p><jats:bold>Results\/Conclusion: <\/jats:bold> Three out of four patients had undetectable serum HCV\u2010RNA, normal levels of aminotransferases and substantially lower or undetectable levels of cryoglobulins at the end of treatment and at 24 weeks follow\u2010up period. Treatment was well tolerated and all patients exhibited significant improvement of neuropathy based on solid clinical and laboratory criteria that was associated with the virological response.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2006.01436.x","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T11:23:22Z","timestamp":1170933802000},"page":"414-420","source":"Crossref","is-referenced-by-count":7,"title":["Severe hepatitis C virus\u2010related cryoglobulinaemic sensory\u2013motor polyneuropathy treated with pegylated interferon\u2010a2b and ribavirin: clinical, laboratory and neurophysiological study"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Koskinas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kilidireas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Karandreas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kountouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Savvas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hadziyannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Archimandritis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199712000-00013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200303000-00006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200001000-00005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(97)80005-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00945029"},{"key":"e_1_2_6_7_2","first-page":"2111","article-title":"Hepatitis C virus infection and Cryoglobulinemia","volume":"2","author":"Lunel L.M.","year":"1996","journal-title":"Viral Hepatitis Reviews"},{"key":"e_1_2_6_8_2","first-page":"805","article-title":"Hepatitis C virus genotype in patients with essential mixed cryoglobulinaemia","volume":"88","author":"Sinico RA","year":"1995","journal-title":"Q J Med"},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"Epidemiology, clinical spectrum and prognostic value of mixed cryoglobulinaemia in hepatitis C virus patients","volume":"28","author":"Adinolfi LE","year":"1996","journal-title":"a prospective study"},{"key":"e_1_2_6_10_2","first-page":"1847","article-title":"Serum cryoglobulin and chronic hepatitis C virus disease among Japanese patients","volume":"90","author":"Tanaka K","year":"1995","journal-title":"Am J Gastroenterology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80054-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2003.00560.x"},{"key":"e_1_2_6_13_2","first-page":"131","article-title":"Cryoglobulinemic neuropathy related to hepatitis C virus infection. 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