{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:50:54Z","timestamp":1780581054465,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T00:00:00Z","timestamp":1189036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although chronic hepatitis C (CH\u2010C) has consistently been shown to impair patients' health\u2010related quality of life (HRQL), the impact of chronic hepatitis B (CH\u2010B) on HRQL has not been fully explored.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> Compare HRQL between patients with CH\u2010B, CH\u2010C, primary biliary cirrhosis (PBC) and healthy controls.<\/jats:p><jats:p><jats:bold>Design: <\/jats:bold> Three HRQL questionnaires [Chronic Liver Disease Questionnaire (CLDQ), Short Form 36 (SF\u201036) and the Health Utility Index (HUI Mark\u20102 and Mark\u20103)] were administered prospectively. Additional clinical and laboratory data and normative data for healthy individuals, were available.<\/jats:p><jats:p><jats:bold>Analysis: <\/jats:bold> Scores were compared using analysis of variance and multiple regression.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> One hundred and forty\u2010six patients with CH\u2010B, CH\u2010C and PBC were included [mean age 47.1 years (\u00b111.6), 41% female, 33% cirrhosis]. CH\u2010C and PBC patients scored the lowest on all CLDQ, SF\u201036 and HUI domains compared with CH\u2010B patients and healthy controls. CH\u2010B patients had scores similar to the healthy population, measured by most CLDQ and SF\u201036 scales. However, the HUI scores for CH\u2010B patients showed more impairment than population norms. Having CH\u2010B and not having cirrhosis were predictive of utility and HRQL scores in multivariate models.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> CH\u2010B patients have better HRQL than CH\u2010C, PBC and population norms. CH\u2010B patients' overall utility scores are lower than population norms.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2007.01558.x","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T08:54:07Z","timestamp":1189241647000},"page":"1119-1125","source":"Crossref","is-referenced-by-count":64,"title":["Health\u2010related quality of life in patients with chronic hepatitis B"],"prefix":"10.1111","volume":"27","author":[{"given":"Silvia","family":"Bondini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Kallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Younoszai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lolita","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zobair M.","family":"Younossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200411003-00008"},{"key":"e_1_2_6_3_2","unstructured":"US CDC.Hepatitis B fact sheet. 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