{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:01:06Z","timestamp":1794373266943,"version":"4.9.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims: <\/jats:bold> Autoimmune hepatitis (AIH) is a progressive liver disease characterized by the presence of circulating autoantibodies, hypergammaglobulinaemia and a favourable response to immunosuppressive treatment. Although the pathogenesis of type 1 AIH is unknown, disease susceptibility is partially determined by genes linked to the class II region of the major histocompatibility complex. Type 1 AIH has been associated with DRB1<jats:sup>*<\/jats:sup>03, DRB1<jats:sup>*<\/jats:sup>04 and DRB3 alleles in European and North American Caucasians, with DRB1<jats:sup>*<\/jats:sup>0405 in Japanese, with DRB1<jats:sup>*<\/jats:sup>0404 in Mexican, and with DRB1<jats:sup>*<\/jats:sup>1301 in Argentinean populations.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> To analyse the molecular basis of these associations in Venezuela (mestizo population), we examined the frequency of human leucocyte antigens (HLA)\u2010A \u2010B \u2010C, HLA\u2010DQ and HLA\u2010DR genes by low\u2010 and high\u2010resolution oligonucleotide typing in a population of 41 type 1 AIH patients and 111 ethnic\u2010 and aged\u2010matched healthy subjects.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The frequencies of both DRB1<jats:sup>*<\/jats:sup>1301 (<jats:italic>P<\/jats:italic>&lt;0.0001) and DRB1<jats:sup>*<\/jats:sup>0301 (<jats:italic>P<\/jats:italic>&lt;0.005) were significantly higher in patients than in controls. In addition, patients showed a strong association with the DRB3 allele (<jats:italic>P<\/jats:italic>&lt;0.01). In contrast, the DQB1<jats:sup>*<\/jats:sup>04 allele was significantly decreased in the patient group (<jats:italic>P<\/jats:italic>&lt;0.01). The frequencies of haplotypes A<jats:sup>*<\/jats:sup>01\u2010B<jats:sup>*<\/jats:sup>08\u2010DQB1<jats:sup>*<\/jats:sup>02\u2010DRB1<jats:sup>*<\/jats:sup>03\u2010DRB3, DQB1<jats:sup>*<\/jats:sup>05\u2010DRB1<jats:sup>*<\/jats:sup>1301, DQB1<jats:sup>*<\/jats:sup>06\u2010DRB1<jats:sup>*<\/jats:sup>1301 and A<jats:sup>*<\/jats:sup>02\u2010DRB1<jats:sup>*<\/jats:sup>1301, B<jats:sup>*<\/jats:sup>45\u2010DRB3 were significantly increased in type 1 AIH patients compared with the controls (<jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> In conclusion, our data indicate that type 1 AIH predisposition in a Venezuelan mestizo population of different ethnic backgrounds is associated with DRB1<jats:sup>*<\/jats:sup>1301 and DRB1<jats:sup>*<\/jats:sup>0301 alleles. In addition, our findings suggest that protection against disease might be conferred by the DQB1<jats:sup>*<\/jats:sup>04 allele, with distinct ethnic differences from other populations.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2007.01581.x","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T13:07:10Z","timestamp":1282914430000},"page":"1409-1416","source":"Crossref","is-referenced-by-count":44,"title":["Genetic contribution of major histocompatibility complex class II region to type 1 autoimmune hepatitis susceptibility in Venezuela"],"prefix":"10.1111","volume":"27","author":[{"given":"Mar\u00eda del Pilar","family":"Fortes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma V.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisselle","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Fern\u00e1ndez\u2010Mestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Dagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto V.","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s E.","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tassinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70476-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017401.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020166605016"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90427-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190311"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250211"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120609"},{"key":"e_1_2_7_9_2","first-page":"1374","article-title":"Pediatric and adult forms of type 1 autoimmune hepatitis in Argentina","volume":"30","author":"Pando M","year":"1999","journal-title":"evidence for differential genetic predisposition"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24562"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80347-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(97)00088-8"},{"key":"e_1_2_7_13_2","first-page":"242","article-title":"Acentral haplotypes","volume":"34","author":"Degli\u2010Esposti MA","year":"1992","journal-title":"conserved population MHC haplotypes"},{"key":"e_1_2_7_14_2","first-page":"998","article-title":"Meeting report","volume":"18","author":"Johnson PJ","year":"1993","journal-title":"international autoimmune hepatitis group"},{"key":"e_1_2_7_15_2","first-page":"225","article-title":"HLA\u2010DR typing by PCR amplification with sequence\u2010specific primers (PCR\u2010SSP) in 2 hours","volume":"39","author":"Olerup O","year":"1992","journal-title":"an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01285.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1981.tb01404.x"},{"key":"e_1_2_7_18_2","unstructured":"ScheneiderS RoessliD ExcoffierL.Arlequin (data analysis software system) 2000; 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