{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T07:13:58Z","timestamp":1697354038140},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T00:00:00Z","timestamp":1195516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Hepatitis A infection, a vaccine\u2010preventable disease, is an important cause of fulminant hepatic failure (FHF) in children in Argentina. Universal vaccination in 1\u2010year\u2010old children was implemented in June 2005. The limited studies about the correlation between the characteristics of the hepatitis A virus (HAV) and FHF have been carried out in adults.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Samples from 41 children with FHF were studied from September 2003 to January 2006 and HAV RNA was detected, sequenced and analysed in the 5\u2032 non\u2010coding region and VP1\/2A region.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Eighteen HAV strains were characterized and found to be different at the nucleotide level from the self\u2010limited acute infection strains that have been circulating in Argentina with no temporal or geographical pattern. They did not form a genetic cluster, but some of them were identical in the largest fragment characterized and some of them seemed to be more closely related in time and\/or geographically.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Our results suggest that viral factors could be involved in the severity of the clinical presentation of HAV infection in children in Argentina.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2007.01634.x","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T13:10:20Z","timestamp":1282914620000},"page":"47-53","source":"Crossref","is-referenced-by-count":17,"title":["Molecular characterization of hepatitis A virus in children with fulminant hepatic failure in Argentina"],"prefix":"10.1111","volume":"28","author":[{"given":"Mar\u00eda 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