{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:47:07Z","timestamp":1778975227632,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T00:00:00Z","timestamp":1205366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\/Aims: <\/jats:bold> Oxidative DNA damage by reactive oxygen species is involved in the process of liver carcinogenesis. To test the hypothesis that a remedy containing <jats:italic>Scutellaria baicalensis<\/jats:italic> Georgi (Sb) and <jats:italic>Bupleurum scorzonerifolfium<\/jats:italic> Willd (Bs) (Sb\/Bs remedy) modulates hepatic neoplastic growth, BOP (<jats:italic>N<\/jats:italic>\u2010nitrosobis(2\u2010oxopropyl)amine)\u2010induced liver cancers in hamsters were established.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Parameters such as survival rate, tumour area, tumour foci, 8\u2010hydroxydeoxyguanosine (8\u2010OHdG), caspase\u20103, transforming growth factor (TGF\u2010\u03b21) and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were measured after Sb\/Bs remedy treatment during BOP\u2010induced carcinogenesis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The results showed that the Sb\/Bs remedy and its constituents Sb and Bs suppressed the tumour area in BOP\u2010induced liver tumours. Because selenium (Sel) is toxic at a high dose (10\u2003mg\/kg), with a low survival rate (0%), the combination of Sb\/Bs remedy and low\u2010dose Sel (1\u2003mg\/kg) was found to decrease the tumour area and the number of tumour foci while increasing serum TNF\u2010\u03b1 and TGF\u2010\u03b21, but not IL\u20106 levels. Besides, the Sb\/Bs remedy, when combined with low\u2010dose Sel, not only decreased the expression of 8\u2010OHdG and increased caspase\u20103 expression within the glutathione <jats:italic>S<\/jats:italic>\u2010transferase placental form\u2010positive tumour foci but also increased tumour apoptosis in BOP\u2010induced hamsters.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> We conclude that low\u2010dose Sel has a chemoprevention effect on BOP\u2010induced liver tumours and such an effect was more enhanced when combined with Sb\/Bs treatment.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2008.01698.x","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T13:20:59Z","timestamp":1282915259000},"page":"841-855","source":"Crossref","is-referenced-by-count":12,"title":["Chemopreventive effect of selenium and Chinese medicinal herbs on <i>N<\/i>\u2010nitrosobis(2\u2010oxopropyl)amine\u2010induced hepatocellular carcinoma in Syrian 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