{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:06:36Z","timestamp":1755925596074},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Nonanastomotic biliary strictures (NAS) are a serious complication after orthotopic liver transplantation (OLT). Matrix metalloproteinases (MMPs) are involved in connective tissue remodelling in chronic liver disease and complications after OLT.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> To evaluate the relationship between MMP\u20102 and MMP\u20109 gene polymorphisms and NAS.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> MMP\u20102 (\u22121306 C\/T) and MMP\u20109 (\u22121562 C\/T) gene promoter polymorphisms were analysed in 314 recipient\u2013donor combinations. Serum levels of these MMPs were determined in subgroups of patients as well. NAS were identified with various radiological imaging studies performed within 4 years after OLT and defined as any stricture, dilation or irregularity of the intra\u2010 or extrahepatic bile ducts of the liver graft followed by an intervention, after exclusion of hepatic artery thrombosis and anastomotic strictures.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The average incidence of NAS was 15%. The major clinical risk factor for the development of NAS was PSC in the recipient. The presence of the MMP\u20102 CT genotype in donor and\/or recipient was associated with a significantly higher incidence of NAS, up to 29% when both donor and recipient had the MMP\u20102 CT genotype (<jats:italic>P<\/jats:italic>=0.003). In the multivariate analyses, pre\u2010OLT PSC (hazard ratio 2.1, <jats:italic>P<\/jats:italic>=0.02) and MMP\u20102 CT genotype (hazard ratio 3.5, <jats:italic>P<\/jats:italic>=0.003) were found to be independent risk factors for the development of NAS after OLT. No obvious association was found between NAS and the MMP\u20109 genotype and serum levels of the MMPs.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> MMP\u20102 CT genotype of donor and recipient is an independent risk factor, in addition to PSC, for the development of NAS after OLT.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2011.02459.x","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T06:46:15Z","timestamp":1296542775000},"page":"1110-1117","source":"Crossref","is-referenced-by-count":18,"title":["Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation"],"prefix":"10.1111","volume":"31","author":[{"given":"W. 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