{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:50:18Z","timestamp":1781221818955,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:00:00Z","timestamp":1301356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            <jats:bold>Background: <\/jats:bold> Hepatitis B virus (HBV) recurrence is a major risk factor affecting the long\u2010term survival of recipients for liver transplantation (LTx). Therefore, a model that can assess this risk before transplantation is highly desirable.<\/jats:p><jats:p>\n            <jats:bold>Methods: <\/jats:bold> One hundred and eighty\u2010five consecutive liver transplant recipients because of HBV\u2010related end\u2010stage liver diseases were selected. Their perioperative laboratory examination results, treatment protocol and the status of HBV recurrence were the primary parameters used to assess their risk of post\u2010transplant HBV recurrence. A model that may be generally used to evaluate the risk of post\u2010transplant HBV recurrence was thus established. A cohort for further validation and a cross\u2010validation were designed.<\/jats:p><jats:p>\n            <jats:bold>Results: <\/jats:bold> After a follow\u2010up time of 26.0 \u00b1 10.8 months, the overall HBV recurrence rate was 8.6%. The 1\u2010, 2\u2010 and 3\u2010year cumulative survival rates were 98.5, 89.2 and 83.4% respectively. By correlation with the pretransplant presence of hepatocelluar carcinoma (HCC), serum HBV DNA level and status of antiviral treatment (AVT), the risk assessment model can be summarized using the following equation: RISK=\u22124.378+1.493 \u00d7 HCC+1.286 \u00d7 DNA\u22122.426 \u00d7 AVT. The HBV recurrence rate and survival were found to be significantly different between the recipients with risk scores\u2264\u22122.8 and&gt;\u22122.8. The model was well validated in this work.<\/jats:p><jats:p>\n            <jats:bold>Conclusions: <\/jats:bold> Pretransplant HBV DNA level, presence of HCC, AVT status and post\u2010transplant viral mutation were identified as the major risk factors associated with HBV recurrence after LTx. A novel model incorporating these factors could effectively evaluate the risk of post\u2010transplant HBV recurrence before transplantation.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2011.02500.x","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T02:42:24Z","timestamp":1301452944000},"page":"1477-1484","source":"Crossref","is-referenced-by-count":21,"title":["A novel model for evaluating the risk of hepatitis B recurrence after liver transplantation"],"prefix":"10.1111","volume":"31","author":[{"given":"Xiao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"487","article-title":"Clinical 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