{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:36:42Z","timestamp":1791121002120,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T00:00:00Z","timestamp":1312761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepato\u2010renal syndrome (HRS) is a serious complication in patients with advanced liver disease indicating a very poor prognosis. Nevertheless, effective treatment strategies have been introduced into clinical practice over the last decade. The combined treatment with terlipressin\/albumin has been proven to be effective in most published studies and should be regarded as the standard of care. Norepinephrine or midodrine are possible alternatives when terlipressin is not available. Although there is presently not enough evidence to recommend extracorporeal liver support therapy as a standard procedure in patients with HRS, these concepts constitute promising options that need to be studied in prospective clinical trials.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2011.02586.x","type":"journal-article","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T15:46:07Z","timestamp":1312818367000},"page":"27-30","source":"Crossref","is-referenced-by-count":13,"title":["New insights into the management of hepato\u2010renal syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Dietrich","family":"Hasper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"J\u00f6rres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,8]]},"reference":[{"issue":"1","key":"e_1_2_6_2_2","first-page":"S69","article-title":"Ascites and hepato\u2010renal syndrome in cirrhosis","volume":"38","author":"Arroyo V","year":"2003","journal-title":"pathophysiological basis of therapy and current management"},{"key":"e_1_2_6_3_2","first-page":"5139","article-title":"Terlipressin and hepato\u2010renal syndrome","volume":"16","author":"Magan AA","year":"2010","journal-title":"what is important for nephrologists and hepatologists"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.236133"},{"key":"e_1_2_6_5_2","first-page":"1310","article-title":"Diagnosis, prevention and treatment of hepato\u2010renal syndrome in cirrhosis","volume":"56","author":"Salerno F","year":"2007","journal-title":"Gut"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908053410603"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P195"},{"key":"e_1_2_6_8_2","first-page":"1179","article-title":"Terlipressin for hepato\u2010renal syndrome","volume":"137","author":"Gerbes AL","year":"2009","journal-title":"continuous infusion as an alternative to iv bolus administration"},{"key":"e_1_2_6_9_2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283345524"},{"key":"e_1_2_6_11_2","first-page":"277","article-title":"Improvement of hepato\u2010renal syndrome with extracorporeal albumin dialysis MARS","volume":"6","author":"Mitzner SR","year":"2000","journal-title":"results of a prospective, randomized, controlled clinical trial"},{"issue":"1","key":"e_1_2_6_12_2","first-page":"S3","article-title":"Extracorporeal liver support by fractionated plasma separation and absorption (Prometheus\u00ae) in patients with acute\u2010on\u2010chronic liver failure (HELIOS study)","volume":"52","author":"Rifai K","year":"2010","journal-title":"a prospective randomized controlled multicenter study"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1478-3231.2011.02586.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1478-3231.2011.02586.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:19:18Z","timestamp":1694621958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1478-3231.2011.02586.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,8]]},"references-count":11,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1478-3231.2011.02586.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02586.x","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,8]]}}}