{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:05:56Z","timestamp":1792148756858,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T00:00:00Z","timestamp":1312761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fractionated plasma separation and adsorption (FPSA) is a method of albumin dialysis that is integrated into an extracorporeal liver support device (Prometheus<jats:sup>\u00ae<\/jats:sup>). This concept allows the effective removal of both protein\u2010bound and water\u2010soluble substances without the need for external albumin. Several studies comparing the <jats:italic>in vivo<\/jats:italic> extraction capacities of FPSA and molecular adsorbent recirculating system (MARS) concluded that detoxification by FPSA seems to be more effective than by MARS. Overall, FPSA therapy has been shown to be safe. Over the last few years, the anticoagulation protocol for FPSA therapy was optimised by using regional anticoagulation with citrate to avoid clotting of system components. Recently, the results of a large randomised\u2010controlled multicentre trial (HELIOS) have been presented. Survival after 1 and 3 months was evaluated in 145 patients with acute\u2010on\u2010chronic liver failure comparing FPSA therapy with standard medical treatment versus standard medical treatment alone. There was no statistically significant survival benefit for patients undergoing FPSA therapy. However, patients with hepatorenal syndrome type I or MELD score&gt;30 showed a significant survival benefit under FPSA in a predefined subgroup analysis. Furthermore, there have been promising results with FPSA in the treatment of refractory cholestatic pruritus. Regarding acute liver failure, only few data are currently available.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2011.02595.x","type":"journal-article","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T15:46:07Z","timestamp":1312818367000},"page":"13-15","source":"Crossref","is-referenced-by-count":18,"title":["Fractionated plasma separation and adsorption: current practice and future options"],"prefix":"10.1111","volume":"31","author":[{"given":"Kinan","family":"Rifai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,8]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"81","article-title":"Fractionated plasma separation and adsorption system","volume":"23","author":"Falkenhagen D","year":"1999","journal-title":"a novel system for blood purification to remove albumin bound substances"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00468-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086885"},{"key":"e_1_2_6_5_2","first-page":"451","article-title":"In vivo quantification of liver dialysis","volume":"43","author":"Krisper P","year":"2005","journal-title":"comparison of albumin dialysis and fractionated plasma separation"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-927385"},{"key":"e_1_2_6_7_2","first-page":"267","article-title":"Technology insight","volume":"3","author":"Krisper P","year":"2007","journal-title":"artificial extracorporeal liver support \u2013 how does Prometheus compare with MARS?"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2009.00762.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc5119"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc4985"},{"key":"e_1_2_6_11_2","first-page":"729A","article-title":"Citrate anticoagulated modified fractionated plasma separation and adsorption","volume":"14","author":"Herget\u2010Rosenthal S","year":"2003","journal-title":"first clinical efficacy and safety data in liver failure"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01909.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02313.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00793.x"},{"issue":"1","key":"e_1_2_6_15_2","first-page":"3","article-title":"Extracorporeal liver support by Fractionated Plasma Separation and Adsorption (Prometheus) in patients with acute\u2010on\u2010chronic liver failure (HELIOS study)","volume":"52","author":"Rifai K","year":"2010","journal-title":"A prospective randomized controlled multicenter study"},{"key":"e_1_2_6_16_2","first-page":"195","article-title":"The treatment of acute liver failure with fractionated plasma separation and adsorption system","volume":"25","author":"Senturk E","year":"2010","journal-title":"experience in 85 applications"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600610154"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1478-3231.2011.02595.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1478-3231.2011.02595.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:19:40Z","timestamp":1694621980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1478-3231.2011.02595.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,8]]},"references-count":16,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1478-3231.2011.02595.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02595.x","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,8]]}}}