{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:00:55Z","timestamp":1781330455032,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T00:00:00Z","timestamp":1322611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Hepatitis B virus surface antigen (<jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content>) quantification has been suggested to discriminate inactive carriers from hepatitis e antigen (<jats:styled-content style=\"fixed-case\">HBeAg<\/jats:styled-content>) negative chronic hepatitis, but it could be genotype\u2010dependent. We studied the predictive value of <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> quantification in genotype C <jats:styled-content style=\"fixed-case\">HBeAg<\/jats:styled-content>\u2010negative hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 104 <jats:styled-content style=\"fixed-case\">HBeAg<\/jats:styled-content>\u2010negative <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> carriers with <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> levels\u00a0&lt;\u00a02,000\u00a0IU\/ml and normal alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) levels for at least 12\u00a0months and prospectively followed them for\u00a0&gt;\u00a036\u00a0months. Patients were classified into two groups: inactive carriers (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) who showed <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> levels\u00a0&lt;\u00a02,000\u00a0IU\/ml and persistently <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\u00a0\u2264\u00a040\u00a0IU\/ml throughout the follow\u2010up period and patients with <jats:styled-content style=\"fixed-case\">HBeAg<\/jats:styled-content>\u2010negative chronic hepatitis (<jats:styled-content style=\"fixed-case\">ENH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After follow\u2010up, 73 patients were categorized into the <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> group and 31 patients into the <jats:styled-content style=\"fixed-case\">ENH<\/jats:styled-content> group. <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> levels were significantly lower in the <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">ENH<\/jats:styled-content> group. The diagnostic accuracy of single\u2010point <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> levels for predicting viral activation was favourable (AUROC\u00a0=\u00a00.710, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Diagnostic accuracy improved when <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg was combined with baseline <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> levels (AUROC\u00a0=\u00a00.750, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The combination of <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> levels\u00a0&gt;\u00a0850\u00a0IU\/ml and <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content>\u00a0&gt;\u00a0850\u00a0IU\/ml predicted the reactivation of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> replication with 84.6% diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although it is inferior to other genotypes and to serum <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> alone, single\u2010point <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> level has a favourable diagnostic accuracy in genotype C <jats:styled-content style=\"fixed-case\">HBeAg<\/jats:styled-content>\u2010negative <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> carriers and is expected to provide additional information for managing chronic hepatitis B.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2011.02693.x","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T17:40:17Z","timestamp":1322761217000},"page":"796-802","source":"Crossref","is-referenced-by-count":29,"title":["Predictive value of <scp>HBsAg<\/scp> quantification for determining the clinical course of genotype C <scp>HBeAg<\/scp>\u2010negative carriers"],"prefix":"10.1111","volume":"32","author":[{"given":"Hana","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine CHA University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hee","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Seoul Korea"},{"name":"Brain Korea 21 Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang\u2010Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Seoul Korea"},{"name":"Brain Korea 21 Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae 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