{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T17:27:52Z","timestamp":1780766872710,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T00:00:00Z","timestamp":1325203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Although the outcome of autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) is generally good, the natural course and likelihood of progression to cirrhosis or hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) remain undefined, and may vary by region and population structure. Our aims were to evaluate risk factors that contribute to poor outcome and particularly development of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in a prospective multicentric cohort study of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group comprised 193 Japanese patients with <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> who were prospectively followed up at annual intervals between 1995 and 2008. The mean follow\u2010up period was 8.0\u00a0\u00b1\u00a04.5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one (10.9%) patients had cirrhosis at presentation and a further 15 (7.8%) developed cirrhosis during the follow\u2010up period. Survival rates were 94.2% at 10\u00a0years and 89.3% at 15\u00a0years. <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> was diagnosed in seven of the 193 patients. The presence of cirrhosis at presentation was a risk factor for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> according to a Cox proportional hazard model, and the <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\u2010free survival rate was significantly lower in those with cirrhosis compared to those without cirrhosis according to Kaplan\u2013Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the outcome of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> is as good if not better among Japanese than for other populations, there was an increased risk of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in these patients. Cirrhosis at presentation was predictive of development of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2011.02734.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T15:17:49Z","timestamp":1325258269000},"page":"837-844","source":"Crossref","is-referenced-by-count":46,"title":["Hepatocellular carcinoma and survival in patients with autoimmune hepatitis (<scp>J<\/scp>apanese <scp>N<\/scp>ational <scp>H<\/scp>ospital <scp>O<\/scp>rganization\u2010autoimmune hepatitis prospective study)"],"prefix":"10.1111","volume":"32","author":[{"given":"Kiyoshi","family":"Migita","sequence":"first","affiliation":[{"name":"Clinical Research Center NHO Nagasaki Medical Center Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Clinical Research Center NHO Nagasaki Medical Center Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Jiuchi","sequence":"additional","affiliation":[{"name":"Clinical Research Center NHO Nagasaki Medical Center Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Clinical Research Center NHO Nagasaki Medical Center Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Saito","sequence":"additional","affiliation":[{"name":"Clinical Research Center NHO Nagasaki Medical Center Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyasu","family":"Yagura","sequence":"additional","affiliation":[{"name":"Clinical Research Center NHO Nagasaki 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