{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:22:04Z","timestamp":1777530124564,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T00:00:00Z","timestamp":1325203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acoustic radiation force impulse (<jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content>) imaging is a new non\u2010invasive, ultrasound\u2010based method for the evaluation of liver fibrosis and cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the diagnostic accuracy of <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> imaging, transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) and Fibrotest for the evaluation of complications in patients with cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 166 patients (109 male, mean age: 54\u00a0\u00b1\u00a011\u00a0years) with chronic liver disease and established cirrhosis were included in this study. <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content>\u2010imaging of the liver and spleen, <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and Fibrotest were performed in all patients. In addition, clinical, laboratory and morphological parameters, including <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2013<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh scores, presence of oesophageal varices and hepatocellular carcinoma, history of variceal bleeding and history of hepatic encephalopathy were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acoustic radiation force impulse liver was significantly correlated with <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> spleen (<jats:italic>r\u00a0<\/jats:italic>=\u00a00.48, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> (<jats:italic>r\u00a0<\/jats:italic>=\u00a00.75, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and Fibrotest (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.21, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.006). The diagnostic accuracy (<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>) for the diagnosis of large oesophageal varices was 0.58 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.48\u20130.67), 0.58 (0.49\u20130.67), 0.53 (0.44\u20130.63) and 0.50 (0.41\u20130.59) for <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> liver, spleen, <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and Fibrotest respectively (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.20). The <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content> for the detection of hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) was 0.54 (0.39\u20130.70), 0.58 (0.44\u20130.73), 0.56 (0.40\u20130.73) and 0.72 (0.60\u20130.84) respectively (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.20). Multiple logistic regression analysis showed that <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> spleen better predicted the presence of large oesophageal varices and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The diagnostic accuracy of <jats:styled-content style=\"fixed-case\">ARFI<\/jats:styled-content> liver and spleen was comparable to <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and Fibrotest for the detection of complications in patients with cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2011.02736.x","type":"journal-article","created":{"date-parts":[[2011,12,30]],"date-time":"2011-12-30T15:18:07Z","timestamp":1325258287000},"page":"852-858","source":"Crossref","is-referenced-by-count":70,"title":["Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis"],"prefix":"10.1111","volume":"32","author":[{"given":"Johannes","family":"Vermehren","sequence":"first","affiliation":[{"name":"Medizinische Klinik 1 Klinikum der J. 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