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It is most often found in patients with advanced cirrhosis. It is clinically relevant during stressful conditions, such as sepsis, bleeding and surgery. <jats:styled-content style=\"fixed-case\">CCM<\/jats:styled-content> reverses after liver transplantation and potentially has a role in the pathogenesis of hepatorenal syndrome. In adrenal insufficiency (<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>), cardiac dysfunction is a feature with low ejection fraction, decreased left ventricular chamber size and electrocardiographic abnormalities, including <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> interval prolongation. With optimal diagnostic tests, <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> is present in approximately 10% of patients with cirrhosis, particularly in those with advanced disease. Down\u2010regulation and decreased number of beta\u2010adrenergic receptors, and high catecholamine levels are common to both cardiac conditions. Thus, <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> may play a role in <jats:styled-content style=\"fixed-case\">CCM<\/jats:styled-content>. Steroid replacement therapy reverses cardiac changes in <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>, and may do so for <jats:styled-content style=\"fixed-case\">CCM<\/jats:styled-content>, with important therapeutic implications; this needs formal evaluation.<\/jats:p>","DOI":"10.1111\/j.1478-3231.2011.02751.x","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T02:17:25Z","timestamp":1328062645000},"page":"1327-1332","source":"Crossref","is-referenced-by-count":42,"title":["Cardiac dysfunction in cirrhosis \u2013 does adrenal function play a role? 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