{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:40:20Z","timestamp":1761561620631},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Abstract<\/jats:title>Background\/Aims<\/jats:title>Pre\u2010diabetes is a risk factor for type 2 diabetes mellitus (DM<\/jats:styled-content>) development. This study aimed to elucidate the impact of treatment response on sequential changes in glucose abnormalities in pre\u2010diabetic chronic hepatitis C<\/jats:styled-content> (CHC<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>C<\/jats:styled-content>hronic H<\/jats:styled-content>epatitis C<\/jats:styled-content> patients with a baseline haemoglobin A<\/jats:styled-content>1C<\/jats:styled-content> (A<\/jats:styled-content>1C<\/jats:styled-content>) range 5.7\u20136.4% who achieved 80\/80\/80 adherence were prospectively recruited. All patients received current peginterferon\u2010based recommendations. The primary outcome measurement was their A<\/jats:styled-content>1C<\/jats:styled-content> level at the end of follow\u2010up (EOF<\/jats:styled-content>). The interaction between variants of the IL<\/jats:styled-content>28B<\/jats:styled-content> gene and outcomes of glucose metabolism was also measured.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 181 consecutive CHC<\/jats:styled-content> patients were enrolled. The mean A<\/jats:styled-content>1C<\/jats:styled-content> at EOF<\/jats:styled-content> was 5.82\u00a0\u00b1\u00a00.41%, which was significantly lower than the baseline level (5.93\u00a0\u00b1\u00a00.21%, P<\/jats:italic>\u00a0<\u00a00.001). At EOF<\/jats:styled-content>, 63 (34.8%) patients became normoglycaemic, whereas 10 (5.5%) patients developed DM<\/jats:styled-content>. The sustained virological response (SVR<\/jats:styled-content>) rates of 63 normoglycaemics, 108 pre\u2010diabetics and 10 diabetic patients at the EOF<\/jats:styled-content> were 92.1%, 84.3% and 50% respectively (normoglycaemics vs. diabetics P<\/jats:italic>\u00a0=\u00a00.003; pre\u2010diabetics vs. diabetics P<\/jats:italic>\u00a0=\u00a00.02). Achievement of an SVR<\/jats:styled-content> was the only predictive factor associated with normoglycaemia development at EOF<\/jats:styled-content> by multivariate logistic regression analysis (Odds ratio\u00a0=\u00a02.6, P<\/jats:italic>\u00a0=\u00a00.04). The prevalence of the interleukin 28B<\/jats:styled-content> rs8099917 TT<\/jats:styled-content> variant in patients who developed DM<\/jats:styled-content> (70.0%) at EOF<\/jats:styled-content> tended to be lower than that in patients with pre\u2010diabetics (87.0%) or normoglycaemics (92.1%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Successful eradication of HCV<\/jats:styled-content> improves glucose abnormalities in pre\u2010diabetic CHC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2012.02771.x","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T04:40:07Z","timestamp":1329972007000},"page":"962-969","source":"Crossref","is-referenced-by-count":19,"title":["The outcomes of glucose abnormalities in pre\u2010diabetic chronic hepatitis C<\/scp> patients receiving peginterferon plus ribavirin 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